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BIBW2992 (Afatinib)是酪氨酸激酶抑制剂（TKI），它不可逆地抑制人表皮生长因子受体2（Her2）和表皮生长因子受体（EGFR）激酶。
靶点信息
| EGFR (L858R) (Cell-free assay) | EGFR (wt) (Cell-free assay) | EGFR (L858R/T790M) (Cell-free assay) | HER2 (Cell-free assay) | |
| 0.4 nM | 0.5 nM | 10 nM | 14 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.58 mL | 102.9 mL | 205.8 mL |
| 0.5 mM | 4.12 mL | 20.58 mL | 41.16 mL |
| 1 mM | 2.06 mL | 10.29 mL | 20.58 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
*The above data is based on the productmolecular weight 485.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10141 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 485.9 |
| Formula | C24H25ClFN5O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 439081-18-2 |
| Synonyms | Tomtovok,Afatinib |
| SMILES | CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4 |
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