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Bictegravir，也称为GS-9883，是一种有效的，未经增强的，每日一次的HIV-1整合酶链转移抑制剂（INSTI）（IC50-1.6 nM），具有改善的药代动力学和体外耐药性。
| In vitro | DMSO | 86 mg/mL (191.37 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.25 mL | 111.26 mL | 222.53 mL |
| 0.5 mM | 4.45 mL | 22.25 mL | 44.51 mL |
| 1 mM | 2.23 mL | 11.13 mL | 22.25 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.45 mL |
*The above data is based on the productmolecular weight 449.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A17011 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 449.38 |
| Formula | C21H18F3N3O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1611493-60-7 |
| Synonyms | GS-9883, GS 9883, GS9883 |
| SMILES | O=C(C1=CN(C2=C(O)C1=O)C[C@@]3([H])O[C@](C4)([H])CC[C@]4([H])N3C2=O)NCC5=C(F)C=C(F)C=C5F |
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