BIIB021

Name: BIIB021
SKU: A10143
Price: 245 CNY
Rating: 5 (6 reviews)

目录号: A10143

HSP90 抑制剂

6 篇发表文献

BIIB021 是一种口服全合成的 Hsp90 抑制剂，它选择性地且强效地抑制分子伴侣 Hsp90，从而抑制多种与肿瘤生长和存活相关的致癌蛋白的正确组装。

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Grouped product items
规格	价格	库存
5mg	¥245.00	现货
10mg	¥420.00	现货
25mg	¥700.00	现货
50mg	¥1,155.00	现货
100mg	¥1,785.00	现货
200mg	¥3,115.00	现货
500mg	¥5,145.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用BIIB021发表的6篇文献

Aydemir Asdemir, .et al. , Naunyn Schmiedebergs Arch Pharmacol ., 2024, Jan 19 PMID: 38240781

Celia Rouges, .et al. , Microorganisms, 2023, Nov 22;11(12):2837 PMID: 38137982

C M G??ven, .et al. , Eur Rev Med Pharmacol Sci, 2023, Aug;27(15):7299-7308 PMID: 37606138

Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138

Ting-Yu Chang, .et al. , Biomed Pharmacother, 2021, Jun;138:111485 PMID: 33740521

Hiroki Murano, .et al. , Plant Biotechnol Rep, 2017, 11:107-113

生物活性

Discription

BIIB021 is an oral fully synthetic Hsp90 inhibitor that selectively and potently inhibits the molecular chaperone Hsp90 thereby inhibiting the proper assembly of multiple oncogenic proteins involved in tumor growth and survival.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10143
分子式	C14H15ClN6O
分子量	318.8
CAS号	848695-25-0
SMILES	CC1=CN=C(C(=C1OC)C)CN2C=NC3=C2N=C(N=C3Cl)N
其他名称	CNF2024
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	60 mg/mL (188.22 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (6.27 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.37 mL	156.84 mL	313.68 mL
0.5 mM	6.27 mL	31.37 mL	62.74 mL
1 mM	3.14 mL	15.68 mL	31.37 mL
5 mM	0.63 mL	3.14 mL	6.27 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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