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bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7. THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 9.49 mL | 47.45 mL | 94.91 mL |
| 0.5 mM | 1.9 mL | 9.49 mL | 18.98 mL |
| 1 mM | 0.95 mL | 4.75 mL | 9.49 mL |
| 5 mM | 0.19 mL | 0.95 mL | 1.9 mL |
*The above data is based on the productmolecular weight 1053.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18559 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 1053.67 |
| Formula | C52H65ClN12O8S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1604811-14-4 |
| SMILES | O=C(NCCOCCOCCOCCNC(NCCCN(C)C/C=C/C(NC1=CC=C(C(NC2=CC=CC(NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)=C2)=O)C=C1)=O)=O)CCCC[C@@H]6SC[C@]([C@]6([H])N7)([H])NC7=O |
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