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BIO是一种细胞可渗透的双吲哚（靛玉红）化合物，可作为GSK3α/β的强效，选择性，可逆和ATP竞争性抑制剂。IC50值为5 nM。
| In vitro (25°C) | DMSO | 70 mg/mL (196.53 mM) | |
| Water | Insoluble | ||
| Ethanol | 6 mg/mL (16.84 mM) | ||
| In vivo | 5% DMSO+40% PEG 300+5% Tween 80+50%ddH2O | 2 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.08 mL | 140.38 mL | 280.76 mL |
| 0.5 mM | 5.62 mL | 28.08 mL | 56.15 mL |
| 1 mM | 2.81 mL | 14.04 mL | 28.08 mL |
| 5 mM | 0.56 mL | 2.81 mL | 5.62 mL |
*The above data is based on the productmolecular weight 356.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A17129 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 356.18 |
| Formula | C16H10BrN3O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 667463-62-9 |
| Synonyms | GSK3 Inhibitor IX, MLS 2052, MLS-2052, MLS2052 |
| SMILES | O=C(/C1=C2NC3=C(C\2=N/O)C=CC=C3)NC4=C1C=CC(Br)=C4 |
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