BIO
目录号: A17129
GSK3 抑制剂
BIO 是一种细胞渗透性的双吲哚（吲哚红）化合物，作为 GSK3α/β 的高效、选择性、可逆、ATP竞争性抑制剂，其 IC50 值为 5 nM。
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生物活性
| Discription | BIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3α/β with IC50 value of 5 nM. | ||
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产品信息
| 目录号 | A17129 |
|---|---|
| 分子式 | C16H10BrN3O2 |
| 分子量 | 356.18 |
| CAS号 | 667463-62-9 |
| SMILES | O=C(/C1=C2NC3=C(C\2=N/O)C=CC=C3)NC4=C1C=CC(Br)=C4 |
| 其他名称 | GSK3 Inhibitor IX, MLS 2052, MLS-2052, MLS2052 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 70 mg/mL (196.53 mM) | |
| Water | Insoluble | ||
| Ethanol | 6 mg/mL (16.84 mM) | ||
| In vivo | 5% DMSO+40% PEG 300+5% Tween 80+50%ddH2O | 2 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.08 mL | 140.38 mL | 280.76 mL |
| 0.5 mM | 5.62 mL | 28.08 mL | 56.15 mL |
| 1 mM | 2.81 mL | 14.04 mL | 28.08 mL |
| 5 mM | 0.56 mL | 2.81 mL | 5.62 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 667463-62-9 | 667463-62-9 供应商 | 667463-62-9 花费 | 667463-62-9 生产商 | 订购 667463-62-9 | 667463-62-9 代理商