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Biochanin A (4-Methylgenistein)是一种抗增殖和抗炎剂，可抑制iNOS的表达和脂多糖（LPS）诱导的巨噬细胞中一氧化氮的产生。此外，Biochanin A还具有阻断IκBα和p38 MAPK磷酸化的能力，从而阻止了NF-κB的活化。此外，已观察到生物chanin A抑制IL-6，IL-1β和TNF-α的产生。
靶点信息
| FAAH (rat) | FAAH (mouse) | FAAH (human) | EGFR | |
| 1.4 μM | 1.8 μM | 2.4 μM | 91.5 μM |
| In vitro | DMSO | 51 mg/mL (179.41 mM) | |
| Water | Insoluble | ||
| Ethanol | 8 mg/mL (28.14 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.17 mL | 175.87 mL | 351.74 mL |
| 0.5 mM | 7.03 mL | 35.17 mL | 70.35 mL |
| 1 mM | 3.52 mL | 17.59 mL | 35.17 mL |
| 5 mM | 0.7 mL | 3.52 mL | 7.03 mL |
*The above data is based on the productmolecular weight 284.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10146 |
|---|---|
| M. Wt | 284.3 |
| Formula | C16H12O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 491-80-5 |
| Synonyms | 4-Methylgenistein |
| SMILES | COC1=CC=C(C=C1)C2=COC3=CC(=CC(=C3C2=O)O)O |
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