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Bioymifi是直接靶向DR5的有效且选择性的DR5小分子激动剂，特异性结合DR5的ECD（Kd?1.2 μM），并诱导DR5聚集体的形成和DR5的活化。
| In vitro | DMSO | Warmed: 40 mg/mL (80.91 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.23 mL | 101.15 mL | 202.3 mL |
| 0.5 mM | 4.05 mL | 20.23 mL | 40.46 mL |
| 1 mM | 2.02 mL | 10.11 mL | 20.23 mL |
| 5 mM | 0.4 mL | 2.02 mL | 4.05 mL |
*The above data is based on the productmolecular weight 494.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12908 |
|---|---|
| 作用机制 | Activator (激活剂) |
| M. Wt | 494.32 |
| Formula | C22H12BrN3O4S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1420071-30-2 |
| SMILES | C1=CC(=CC=C1N2C(=O)/C(=C/C3=CC=C(O3)C4=CC5=C(C=C4)C(=O)NC5=O)/SC2=N)Br |
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