BMS-1166
目录号: A13129
PD-1/PD-L1 interaction 抑制剂
BMS-1166 是一种强效的 PD-1/PD-L1 互作抑制剂，其 IC50 为 1.4 nM。BMS-1166 抵消了 PD-1/PD-L1 免疫检查点对 T 细胞激活的抑制作用。
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生物活性
| Discription | BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. | |||||
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| Cell Research |
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产品信息
| 目录号 | A13129 |
|---|---|
| 分子式 | C36H33ClN2O7 |
| 分子量 | 641.11 |
| CAS号 | 1818314-88-3 |
| SMILES | O=C(O)[C@@H]1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C(OCCO5)C5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)C[C@H](O)C1 |
| 其他名称 | BMS 1166, BMS1166 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 91 mg/mL (141.93 mM) | |
| Water | Insoluble | ||
| Ethanol | 12 mg/mL (18.71 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.6 mL | 77.99 mL | 155.98 mL |
| 0.5 mM | 3.12 mL | 15.6 mL | 31.2 mL |
| 1 mM | 1.56 mL | 7.8 mL | 15.6 mL |
| 5 mM | 0.31 mL | 1.56 mL | 3.12 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1818314-88-3 | 1818314-88-3 供应商 | 1818314-88-3 花费 | 1818314-88-3 生产商 | 订购 1818314-88-3 | 1818314-88-3 代理商