BMS 299897

Name: BMS 299897
SKU: A12444
Price: 315 CNY
Rating: 5 (1 reviews)

目录号: A12444

γ-secretase 抑制剂

1 篇发表文献

BMS 299897 是一种口服活性强的 γ-分泌酶抑制剂（IC50 = 12 nM）。在体外抑制 Aβ40 和 Aβ42 的形成（IC50 值分别为 7.4 和 7.9 nM），并在体内减少大脑、血浆和脑脊液中的 Aβ。

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Grouped product items
规格	价格	库存
5mg	¥315.00	现货
10mg	¥595.00	现货
25mg	¥1,190.00	现货
50mg	¥2,065.00	现货
100mg	¥3,920.00	现货
*10mM 1mL in DMSO**	¥350.00	现货
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Data Sheet

SDS

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Adooq用户使用BMS 299897发表的1篇文献

Chao Liu, .et al. , Cell Death Differ, 2018, Apr; 25(4): 661-676 PMID: 29238071

生物活性

Discription	BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo.

产品信息

目录号	A12444
分子式	C24H21ClF3NO4S
分子量	511.94
CAS号	290315-45-6
SMILES	C[C@H](C1=C(C=C(C=C1)F)CCCC(=O)O)N(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
其他名称	BMS 299897
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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