产品详情
BMS 299897是一种有效的γ-分泌酶抑制剂(IC50 = 12 nM)。在体外抑制Aβ40和Aβ42的形成(IC50值分别为7.4和7.9 nM),并在体内降低脑,血浆和脑脊髓液中的Aβ。
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 19.53 mL | 97.67 mL | 195.34 mL |
0.5 mM | 3.91 mL | 19.53 mL | 39.07 mL |
1 mM | 1.95 mL | 9.77 mL | 19.53 mL |
5 mM | 0.39 mL | 1.95 mL | 3.91 mL |
*The above data is based on the productmolecular weight 511.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
目录号 | A12444 |
---|---|
作用机制 | Inhibitor (抑制剂) |
M. Wt | 511.94 |
Formula | C24H21ClF3NO4S |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. |
CAS No. | 290315-45-6 |
Synonyms | BMS 299897 |
SMILES | C[C@H](C1=C(C=C(C=C1)F)CCCC(=O)O)N(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl |
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