Branaplam
目录号: A20714
SMN2 splicing modulator
Branaplam（LMI070）是一种高效、选择性强且口服活性的小分子 SMN2剪接调节剂。
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生物活性
| Discription | Branaplam (LMI070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator. |
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产品信息
| 目录号 | A20714 |
|---|---|
| 分子式 | C22H27N5O2 |
| 分子量 | 393.48 |
| CAS号 | 1562338-42-4 |
| SMILES | OC1=CC(C2=CNN=C2)=CC=C1C3=CC=C(OC4CC(C)(C)NC(C)(C)C4)N=N3 |
| 其他名称 | LMI070, LMI 070, LMI-070; NVS-SM1 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 3 mg/mL (7.62 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.41 mL | 127.07 mL | 254.14 mL |
| 0.5 mM | 5.08 mL | 25.41 mL | 50.83 mL |
| 1 mM | 2.54 mL | 12.71 mL | 25.41 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.08 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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