微信关注
Total item
Cart Subtotal
￥ 0.00 产品详情
BX-795是有效的PDK1抑制剂，可阻断肿瘤细胞中的PDK1/Akt信号传导并抑制培养物中多种肿瘤细胞系的锚定依赖性生长或诱导凋亡。
Targets
| Target | Value | |
|---|---|---|
| TBK1/IKK? | ||
| PDK-1 | IC50: 6nM | |
| c-Kit | IC50: 320nM | |
| CDK2/CyclinE | IC50: 430nM | |
| Chk1 | IC50: 510nM | |
| GSK-3β | IC50: 620nM | |
| PKA | IC50: 840nM | |
| KDR | IC50: 1.1μM | |
| T-Fyn | IC50: 6.4μM | |
| PKC | IC50: 9.3μM | |
| EGFR | IC50: >10μM | |
| Insulin Receptor | IC50: >10μM |
| In vitro (25°C) | DMSO | 88 mg/mL (148.78 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+30% PEG +2% Tween 80+ddH2O | 3 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.91 mL | 84.53 mL | 169.06 mL |
| 0.5 mM | 3.38 mL | 16.91 mL | 33.81 mL |
| 1 mM | 1.69 mL | 8.45 mL | 16.91 mL |
| 5 mM | 0.34 mL | 1.69 mL | 3.38 mL |
*The above data is based on the productmolecular weight 591.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11148 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 591.5 |
| Formula | C23H26IN7O2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 702675-74-9 |
| Synonyms | BX795 |
| SMILES | C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I |
产品标签
Product Questions
Product Questions
No Questions
Keywords:购买 BX-795 | BX-795 供应商 | 订购 BX-795 | BX-795 价格 | BX-795 生产商 | 订单 BX-795 | BX-795 代理商 | 购买 702675-74-9| 702675-74-9 供应商 | 订购 702675-74-9 | 702675-74-9 价格 | 702675-74-9 生产商 | 订单 702675-74-9 | 702675-74-9 代理商|buy BX-795 | BX-795 Supplier | purchase BX-795 | BX-795 cost | BX-795 manufacturer | order BX-795 | BX-795 distributor | buy 702675-74-9| 702675-74-9 Supplier | purchase 702675-74-9 | 702675-74-9 cost | 702675-74-9 manufacturer | order 702675-74-9 | 702675-74-9 distributor