Cabozantinib S-malate
Cabozantinib S-malate (XL184 S-malate) 是一种强效的多重受体酪氨酸激酶抑制剂，能够抑制 VEGFR2、c-Met、Kit、Axl 和 Flt3，其半抑制浓度（IC50）分别为 0.035、1.3、4.6、7 和 11.3 纳摩尔 (nM)。
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生物活性
| Discription | Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively. |
|---|---|
| Targets | |
| Cell Research |
产品信息
| 目录号 | A11349 |
|---|---|
| 分子式 | C32H30FN3O10 |
| 分子量 | 635.59 |
| CAS号 | 1140909-48-3 |
| SMILES | O=C([C@H](CC(O)=O)O)O.O=C(NC1=CC=C(C=C1)OC2=CC=NC3=CC(OC)=C(C=C23)OC)C4(CC4)C(NC5=CC=C(C=C5)F)=O |
| 其他名称 | XL184 S-malate; BMS-907351 S-malate |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 91 mg/mL (143.17 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 14 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.73 mL | 78.67 mL | 157.33 mL |
| 0.5 mM | 3.15 mL | 15.73 mL | 31.47 mL |
| 1 mM | 1.57 mL | 7.87 mL | 15.73 mL |
| 5 mM | 0.31 mL | 1.57 mL | 3.15 mL |
Useful Calculator
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