Cabozantinib S-malate

Name: Cabozantinib S-malate
SKU: A11349
Price: 245 CNY
Rating: 5 (2 reviews)

目录号: A11349

multiple receptor tyrosine kinases 抑制剂

2 篇发表文献

Cabozantinib S-malate (XL184 S-malate) 是一种强效的多重受体酪氨酸激酶抑制剂，能够抑制 VEGFR2、c-Met、Kit、Axl 和 Flt3，其半抑制浓度（IC50）分别为 0.035、1.3、4.6、7 和 11.3 纳摩尔 (nM)。

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Grouped product items
规格	价格	库存
5mg	¥245.00	现货
10mg	¥350.00	现货
50mg	¥455.00	现货
100mg	¥630.00	现货
200mg	¥1,050.00	现货
500mg	¥2,065.00	现货
*10mM 1mL in DMSO**	¥350.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Cabozantinib S-malate发表的2篇文献

Paula Sagmeister, .et al. , J Hepatocell Carcinoma, 2022, Jul 9;9:595-607 PMID: 35845819

Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812

生物活性

Discription

Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11349
分子式	C32H30FN3O10
分子量	635.59
CAS号	1140909-48-3
SMILES	O=C([C@H](CC(O)=O)O)O.O=C(NC1=CC=C(C=C1)OC2=CC=NC3=CC(OC)=C(C=C23)OC)C4(CC4)C(NC5=CC=C(C=C5)F)=O
其他名称	XL184 S-malate; BMS-907351 S-malate
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	91 mg/mL (143.17 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.73 mL	78.67 mL	157.33 mL
0.5 mM	3.15 mL	15.73 mL	31.47 mL
1 mM	1.57 mL	7.87 mL	15.73 mL
5 mM	0.31 mL	1.57 mL	3.15 mL

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