Canertinib dihydrochloride

Name: Canertinib dihydrochloride
SKU: A11344

目录号: A11344

EGFR inhibitor

Canertinib dihydrochloride Chemical Structure

CAS NO. 289499-45-2

Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM.

库存：现货

规格	价格	数量
50 mg	￥ 504.00
100 mg	￥ 868.00
500 mg	￥ 2,576.00

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生物活性

Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM.

溶解度 *

In vitro	DMSO	88 mg/mL (157.46 mM)
	Water	18 mg/mL (32.2 mM)
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.89 mL	89.47 mL	178.94 mL
0.5 mM	3.58 mL	17.89 mL	35.79 mL
1 mM	1.79 mL	8.95 mL	17.89 mL
5 mM	0.36 mL	1.79 mL	3.58 mL

*The above data is based on the productmolecular weight 558.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11344
作用机制	Inhibitor (抑制剂)
M. Wt	558.86
Formula	C24H27Cl3FN5O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	289499-45-2
Synonyms	CI-1033 dihydrochloride; PD-183805 dihydrochloride
SMILES	C=CC(NC1=CC2=C(N=CN=C2C=C1OCCCN3CCOCC3)NC4=CC=C(C(Cl)=C4)F)=O.[H]Cl.[H]Cl