Canertinib dihydrochloride

Name: Canertinib dihydrochloride
SKU: A11344
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A11344

EGFR 抑制剂

Canertinib 二盐酸盐（CI-1033 二盐酸盐）是一种强效且不可逆的 EGFR 抑制剂；它能抑制细胞内 EGFR 和 ErbB2 的自磷酸化，其 IC50 分别为 7.4 和 9 纳摩尔。

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Grouped product items
规格	价格	库存
10mg	¥175.00	现货
25mg	¥210.00	现货
50mg	¥280.00	现货
100mg	¥490.00	现货
500mg	¥1,820.00	现货
*10mM 1mL in DMSO**	¥175.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

Other Forms of Canertinib dihydrochloride

Canertinib (CI-1033)

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生物活性

Discription

Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11344
分子式	C24H27Cl3FN5O3
分子量	558.86
CAS号	289499-45-2
SMILES	C=CC(NC1=CC2=C(N=CN=C2C=C1OCCCN3CCOCC3)NC4=CC=C(C(Cl)=C4)F)=O.[H]Cl.[H]Cl
其他名称	CI-1033 dihydrochloride; PD-183805 dihydrochloride
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	88 mg/mL (157.46 mM)
	Water	18 mg/mL (32.2 mM)
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.89 mL	89.47 mL	178.94 mL
0.5 mM	3.58 mL	17.89 mL	35.79 mL
1 mM	1.79 mL	8.95 mL	17.89 mL
5 mM	0.36 mL	1.79 mL	3.58 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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