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CBL0137 (CBL-0137)在基于细胞的p53和NF-kB报告基因检测中分别激活p53和抑制NF-kB，EC50为0.37 uM和0.47 uM。它还抑制组蛋白伴侣FACT（促进染色质转录复合物）。
| In vitro | DMSO | 35 mg/mL (93.86 mM) | |
| Water | 22 mg/mL (59 mM) | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.82 mL | 134.09 mL | 268.18 mL |
| 0.5 mM | 5.36 mL | 26.82 mL | 53.64 mL |
| 1 mM | 2.68 mL | 13.41 mL | 26.82 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.36 mL |
*The above data is based on the productmolecular weight 372.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16836 |
|---|---|
| 作用机制 | Inhibitor (抑制剂), Activator (激活剂) |
| M. Wt | 372.89 |
| Formula | C21H24N2O2.HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1197397-89-9 |
| Synonyms | CBL0137, CBL 0137, Curaxin 137, Curaxin137, Curaxin-137, CBLC137, CBLC 137, CBLC-137 |
| SMILES | CC(/N=C/CN1C2=C(C3=C1C=CC(C(C)=O)=C3)C=C(C(C)=O)C=C2)C.[H]Cl |
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