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CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.55 mL | 97.76 mL | 195.52 mL |
| 0.5 mM | 3.91 mL | 19.55 mL | 39.1 mL |
| 1 mM | 1.96 mL | 9.78 mL | 19.55 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.91 mL |
*The above data is based on the productmolecular weight 511.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18471 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 511.45 |
| Formula | C26H28Cl2N6O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2206788-99-8 |
| SMILES | ClC(C=C(Cl)C=C1)=C1[C@@H](C)N2N=C(C#N)C3=C2N=C(C4=CC[C@H](N5[C@H](CO)CCC5)[C@H](C)C4)C=N3 |
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