产品详情

生物活性

CCT129202是一种ATP竞争性的pan-Aurora抑制剂，作用于Aurora A，Aurora B和Aurora C时，IC50分别为0.042 μM，0.198 μM和0.227 μM，对FGFR3， GSK3β， PDGFRβ等作用效果稍弱。

靶点信息

Aurora A	Aurora B	Aurora C
42 nM	198 nM	227 nM

溶解度 *

In vitro (25°C)	DMSO	3 mg/mL (6.03 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.12 mL	100.6 mL	201.21 mL
0.5 mM	4.02 mL	20.12 mL	40.24 mL
1 mM	2.01 mL	10.06 mL	20.12 mL
5 mM	0.4 mL	2.01 mL	4.02 mL

*The above data is based on the productmolecular weight 497.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10184
作用机制	Inhibitor (抑制剂)
M. Wt	497.0
Formula	C23H25ClN8OS
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	942947-93-5
Synonyms	CCT-129202
SMILES	CN(C)C1=CC=C(C=C1)C2=NC3=NC=C(C(=C3N2)N4CCN(CC4)CC(=O)NC5=NC=CS5)Cl