微信关注
Total item
Cart Subtotal
￥ 0.00 产品详情
Cediranib (AZD2171)是一种高效的VEGFR(KDR)抑制剂，此外对c-Kit和PDGFRβ也具有相似的抑制活性，对VEGFR的选择性比PDGFR-α，CSF-1R和Flt3分别高36倍，110倍 和1000倍以上。
Targets
| Target | Value |
|---|---|
| VEGFR2/KDR | IC50: 0.5nM |
| c-Kit | IC50: 2nM |
| VEGFR3/FLT4 | IC50: <=3nM |
| VEGFR1/FLT1 | IC50: 5nM |
| PDGFRβ | IC50: 5nM |
| FGFR1 | IC50: 26nM |
| PDGFRα | IC50: 36nM |
| CSF-1R | IC50: 110nM |
| Src | IC50: 130nM |
| Abl | IC50: 260nM |
| FLT3 | IC50: >1μM |
| HER2/ErbB2 | IC50: >1μM |
| CDK2 | IC50: >1μM |
| CDK4 | IC50: >1μM |
| EGFR | IC50: 1.6μM |
| AuroraA | IC50: >10μM |
| AuroraB | IC50: >10μM |
| MEK | IC50: >10μM |
| In vitro (25°C) | DMSO | 80 mg/mL (177.57 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+50% PEG 300+5% Tween+ddH2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.2 mL | 110.99 mL | 221.98 mL |
| 0.5 mM | 4.44 mL | 22.2 mL | 44.4 mL |
| 1 mM | 2.22 mL | 11.1 mL | 22.2 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.44 mL |
*The above data is based on the productmolecular weight 450.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10185 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 450.5 |
| Formula | C25H27FN4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 288383-20-0 |
| Synonyms | Recentin |
| SMILES | CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5 |
产品标签
Product Questions
Product Questions
No Questions
您还可能对下列产品感兴趣
Tivozanib (AV-951)
Tivozanib (AV-951)是一种口服VEGF受体酪氨酸激酶抑制剂，旨在抑制所有三种VEGF受体。
E7080 (Lenvatinib)
E7080 (Lenvatinib)是一种多激酶抑制剂，可同时抑制VEGFR2和VEGFR3激酶。
XL647 (Tesevatinib)
XL647 (Tesevatinib)是一种口服生物可利用的小分子RTK抑制剂，可结合并抑制在肿瘤细胞增殖和肿瘤血管形成中…
ZM 306416
ZM 306416 hydrochloride是一种VEGF受体酪氨酸激酶抑制剂，可抑制KDR（IC50 = 100 nM）和Flt（IC50 = 2 uM）酪氨酸激酶…
NVP-BAW2881
NVP-BAW2881是有效的选择性VEGFR抑制剂（血管内皮生长因子受体酪氨酸激酶抑制剂），IC50 为值9 nM，具有抑制…
XL184 free base (Cabozantinib)
XL184 free base (Cabozantinib)是设计用来抑制多种受体酪氨酸激酶（特别是MET和VEGFR2）的小分子。
Keywords:购买 Cediranib (AZD2171) | Cediranib (AZD2171) 供应商 | 订购 Cediranib (AZD2171) | Cediranib (AZD2171) 价格 | Cediranib (AZD2171) 生产商 | 订单 Cediranib (AZD2171) | Cediranib (AZD2171) 代理商 | 购买 288383-20-0| 288383-20-0 供应商 | 订购 288383-20-0 | 288383-20-0 价格 | 288383-20-0 生产商 | 订单 288383-20-0 | 288383-20-0 代理商|buy Cediranib (AZD2171) | Cediranib (AZD2171) Supplier | purchase Cediranib (AZD2171) | Cediranib (AZD2171) cost | Cediranib (AZD2171) manufacturer | order Cediranib (AZD2171) | Cediranib (AZD2171) distributor | buy 288383-20-0| 288383-20-0 Supplier | purchase 288383-20-0 | 288383-20-0 cost | 288383-20-0 manufacturer | order 288383-20-0 | 288383-20-0 distributor