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Cell Cycle

产品 201 到 250 共 250个

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  1. KJ Pyr 9
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    KJ Pyr 9

    Catalog No. A16324
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    MYC 抑制剂
    KJ Pyr 9是来自Krhnke吡啶库的MYC的新型小分子抑制剂KJ-Pyr-9。 了解更多
  2. ML327
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    ML327

    Catalog No. A17009
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    MYC 抑制剂
    ML327是MYC的阻止者。ML327介导E-钙黏着蛋白的转录去阻遏和上皮到间充质转化的抑制。 了解更多
  3. 10074-G5
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    10074-G5

    Catalog No. A17169
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    c-Myc 抑制剂
    10074-G5是c-Myc抑制剂，可抑制c-Myc/Max异二聚体形成并抑制其转录活性，IC50值为146μM。 了解更多
  4. sAJM589
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    sAJM589

    Catalog No. A18429
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    Myc 抑制剂
    sAJM589 is a Myc inhibitor which potently disrupts the Myc-Max heterodimer with an IC50 of 1.8 μM. 了解更多
  5. MK-1775
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    MK-1775

    Catalog No. A10599
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    WEE1 抑制剂
    MK-1775是一种有效的体外和体内Wee1激酶抑制剂。 了解更多
  6. EHT 1864
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    EHT 1864

    Catalog No. A13886
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    Rac family GTPase 抑制剂
    EHT 1864是一种抑制Rac家族GTPases的抗增殖化学物质。 了解更多
  7. Zoledronic Acid
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    Zoledronic Acid

    Catalog No. A11010
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    osteoclastic bone resorption 抑制剂
    Zoledronic acid, 破骨细胞抑制剂，通过抑制甲羟戊酸途径诱导破骨细胞凋亡。 了解更多
  8. NSC 23766
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    NSC 23766

    Catalog No. A12546
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    Rac1 activation 抑制剂
    SC 23766是Rac1-GEF相互作用的选择性抑制剂。通过Rac特异性鸟嘌呤核苷酸交换因子（GEF）TrioN和Tiam1（IC50为50 μM）阻止Rac1激活，而不影响Cdc42或RhoA激活。 了解更多
  9. GGTI-2418
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    GGTI-2418

    Catalog No. A13112
    GGTase 抑制剂
    GGTI-2418是香叶基香叶基转移酶I（GGTase I）的合成拟肽抑制剂，它似乎通过下调一些关键的致癌和肿瘤生存途径来诱导凋亡。 了解更多
  10. Balamapimod (MKI-833)
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    Balamapimod (MKI-833)

    Catalog No. A13119
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    Ras/Raf/MEK 抑制剂
    Balamapimod (MKI-833)是Ras/Raf/MEK抑制剂。 了解更多
  11. ZCL-278
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    ZCL-278

    Catalog No. A13403
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    Cdc42 GTPase 抑制剂
    ZCL-278是Cdc42的选择性抑制剂。以Cdc42鸟嘌呤核苷酸交换因子交叉蛋白(ITSN)的结合位点为目标。抑制Cdc42介导的细胞效应，包括3T3成纤维细胞中微峰的形成和初生新生皮质神经元中的神经元分支。还抑制PC3细胞的细胞运动和迁移，无细胞毒性作用。 了解更多
  12. Kobe0065
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    Kobe0065

    Catalog No. A13135
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    Ras-Raf interaction 抑制剂
    Kobe0065抑制锚定依赖性和非依赖性生长，阻断MEK / ERK活性并诱导H-rasG12V转化的NIH3T3细胞凋亡。 了解更多
  13. Kobe2602
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    Kobe2602

    Catalog No. A12578
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    Ras–Raf 抑制剂
    Kobe2602是Kobe0065的类似物。表现出有效的活性以竞争性抑制Ki-值为149±55 μM的H-Ras·GTP与c-Raf-1 RBD的结合。 了解更多
  14. EHop-016
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    EHop-016

    Catalog No. A12740
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    Rac GTPase Inhibitor
    EHop-016 is a potent and specific inhibitor of Rac1 and Rac3 GTPase activity that inhibits Vav2 interaction with Rac, Rac-activated PAK1, lamellipodia formation, and cell migration. 了解更多
  15. K-Ras(G12C) inhibitor 6
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    K-Ras(G12C) inhibitor 6

    Catalog No. A14103
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    K-Ras(G12C) 抑制剂
    K-Ras(G12C) inhibitor 6 是致癌性K-Ras（G12C）的不可逆抑制剂，颠覆了天然核苷酸的偏爱性，使GDP优于GTP。 了解更多
  16. K-Ras(G12C) inhibitor 12
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    K-Ras(G12C) inhibitor 12

    Catalog No. A14227
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    K-Ras(G12C) 抑制剂
    K-Ras(G12C) inhibitor 12 是致癌性K-Ras（G12C）的变构抑制剂。 了解更多
  17. 6H05 (trifluoroacetate salt)
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    6H05 (trifluoroacetate salt)

    Catalog No. A14235
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    K-Ras 抑制剂
    6H05 (trifluoroacetate salt)是致癌性K-Ras（G12C）的选择性变构抑制剂。 了解更多
  18. K-Ras(G12C) inhibitor 9
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    K-Ras(G12C) inhibitor 9

    Catalog No. A14250
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    K-Ras(G12C) 抑制剂
    K-Ras(G12C) inhibitor 9是致癌性K-Ras（G12C）的变构抑制剂。 了解更多
  19. NSC-23766 HCl
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    NSC-23766 HCl

    Catalog No. A13975
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    Rac GTPase 抑制剂
    NSC 23766是Rac特异性GEF TrioN和Tiam 1（IC50 = 50 uM）引起的Rac1激活的细胞可渗透性可逆抑制剂。 了解更多
  20. CCG-1423
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    CCG-1423

    Catalog No. A14430
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    Rho 抑制剂
    CCG-1423是Rho途径介导的信号传导和血清反应因子（SRF）转录激活的特异性抑制剂。 了解更多
  21. Salirasib
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    Salirasib

    Catalog No. A11572
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    PPMTase 抑制剂
    Salirasib是Prenylated蛋白甲基转移酶（PPMTase）的抑制剂，Ki值为2.6 uM。 了解更多
  22. XRP44X
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    XRP44X

    Catalog No. A16049
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    Ras-Net 抑制剂
    XRP44X是Ras-Net（Elk-3）途径抑制剂（IC50 = 10-20 nM）。间接抑制Erk1/2激活上游的净磷酸化。 了解更多
  23. 6H05
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    6H05

    Catalog No. A16097
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    K-Ras 抑制剂
    6H05是致癌突变体K-Ras（G12C）的选择性变构抑制剂。 了解更多
  24. APS-2-79 HCl
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    APS-2-79 HCl

    Catalog No. A16175
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    KSR/Ras 抑制剂
    APS-2-79 HCl，稳定KSR（Ras激酶抑制剂）失活状态并拮抗致癌性Ras信号（IC50值为120 nM，对抗KSR2的ATP-生物素探针标记）的小分子。 了解更多
  25. APS-2-79
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    APS-2-79

    Catalog No. A16231
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    KSR/Ras 抑制剂
    APS-2-79是RAF通过直接结合KSR活性位点而使MEK磷酸化的拮抗剂。 了解更多
  26. BQU57
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    BQU57

    Catalog No. A14956
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    GTPase Ral 抑制剂
    BQU57是RBC8的衍生物，是相对于GTPases Ras和RhoA的选择性GTPase Ral抑制剂。 了解更多
  27. ARS-1620
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    ARS-1620

    Catalog No. A16809
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    KRAS-G12C 抑制剂
    ARS-1620是一种有效的口服生物利用性共价抑制剂（KRAS-G12C），可以实现体内靶标的快速，持续存在，从而诱导肿瘤消退。 了解更多
  28. BDP9066
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    BDP9066

    Catalog No. A16874
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    MRCK 抑制剂
    BDP9066是有效的选择性MRCK抑制剂，可减少底物的磷酸化。 了解更多
  29. ARS-1630
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    ARS-1630

    Catalog No. A17061
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    mutant K-ras G12C 抑制剂
    ARS-1630是突变K-ras G12C的新型抑制剂。 了解更多
  30. ARS-1323
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    ARS-1323

    Catalog No. A17060
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    mutant K-ras G12C 抑制剂
    ARS-1323是突变K-ras G12C的新型抑制剂。 了解更多
  31. Antineoplaston A10
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    Antineoplaston A10

    Catalog No. A17183
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    Ras 抑制剂
    Antineoplaston A 10是Ras抑制剂，可能用于治疗神经胶质瘤，淋巴瘤，星形细胞瘤和乳腺癌。 了解更多
  32. MRTX1257
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    • 最新产品

    MRTX1257

    Catalog No. A17223
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    KRAS-G12C inhibitor
    MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM. 了解更多
  33. Ras-IN-3144
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    • 最新产品

    Ras-IN-3144

    Catalog No. A17222
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    pan-RAS inhibitor
    Ras-IN-3144 is a pan-RAS inhibitor which inhibits RAS signaling pathways in cancer cells and prevents the growth of RAS mutant mouse cancer xenografts. 了解更多
  34. AMG-510 racemate
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    AMG-510 racemate

    Catalog No. A18752
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    KRAS G12C covalent inhibitor
    AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity. 了解更多
  35. ZT-12-037-01
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    ZT-12-037-01

    Catalog No. A18395
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    ATP-competitive STK19 inhibitor
    ZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor. ZT-12-037-01 effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vitro and in vivo. 了解更多
  36. KRAS G12C inhibitor 13
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    KRAS G12C inhibitor 13

    Catalog No. A19041
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    KRAS G12C inhibitor
    KRAS G12C inhibitor 13 is a KRAS G12C inhibitor extracted from patent WO2018143315A1, compound 30. 了解更多
  37. KRAS G12C inhibitor 5
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    KRAS G12C inhibitor 5

    Catalog No. A18840
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    KRas G12C inhibitor
    KRAS G12C inhibitor 5 is a KRas G12C inhibitor extracted from patent WO2017201161A1, Compound example 147. 了解更多
  38. KRAS G12C inhibitor 15
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    KRAS G12C inhibitor 15

    Catalog No. A18447
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    KRAS G12C inhibitor
    KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC50 of 5 nM. 了解更多
  39. KRAS G12C inhibitor 16
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    KRAS G12C inhibitor 16

    Catalog No. A18444
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    KRAS G12C inhibitor
    KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 39, has an IC50 of 97 nM. 了解更多
  40. KRAS G12C inhibitor 17
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    KRAS G12C inhibitor 17

    Catalog No. A18441
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    KRAS G12C inhibitor
    KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 82, has an IC50 of 5 nM. 了解更多
  41. EHT 5372
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    EHT 5372

    Catalog No. A12586
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    DYRK inhibitor
    EHT 5372 is a strong inhibitor of DYRK??s family kinases, with IC50s of 0.22, 0.28 nM for DYRK1A and DYRK1B, respectively. 了解更多
  42. LDN-192960 hydrochloride
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    LDN-192960 hydrochloride

    Catalog No. A21390
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    DYRK2 inhibitor
    LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively. 了解更多
  43. ID 8
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    ID 8

    Catalog No. A12922
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    DYRK 抑制剂
    ID-8是DYRK抑制剂。ID 8还以稳定的速率刺激增殖（在30天的补充有10 μM的无血清培养基中观察到）。 了解更多
  44. AZ191
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    AZ191

    Catalog No. A14314
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    DYRK 抑制剂
    AZ191是一种有效的选择性DYRK1B抑制剂，IC50为17 nM，选择性比DYRK1A和DYRK2高5到110倍。 了解更多
  45. Mirk-IN-1
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    Mirk-IN-1

    Catalog No. A16255
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    Dyrk1B 抑制剂
    Mirk-IN-1是有效的Dyrk1B（Mirk kianse）和Dyrk1A抑制剂，IC50分别为68±48 nM和22±8 nM。 了解更多
  46. 360A
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    360A

    Catalog No. A14975
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    G-quadruplex structures 抑制剂
    360A是G四联体结构的强亲和力和选择性抑制剂。 了解更多
  47. 360A iodide
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    360A iodide

    Catalog No. A14976
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    G-quadruplex structures 抑制剂
    360A iodide是G-四链结构的强亲和选择性抑制剂。 了解更多
  48. RI-1
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    RI-1

    Catalog No. A13187
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    RAD51 抑制剂 II
    RI-1是抑制中央重组蛋白RAD51的小分子。RI-1在刺激单链退火的同时特别减少了人类细胞中的基因转化。RI-1与半胱氨酸319处的RAD51蛋白表面共价结合，这可能会使RAD51单体寡聚化成DNA上的细丝所用的界面不稳定。 了解更多
  49. RAD51 Inhibitor B02
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    RAD51 Inhibitor B02

    Catalog No. A18334
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    RAD51 inhibitor
    AD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM. 了解更多
  50. RI-2
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    RI-2

    Catalog No. A20992
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    RAD51 inhibitor
    RI-2 is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM, and specifically inhibits homologous recombination repair in human cells. 了解更多

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