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Androgen Receptor antagonist
醋酸环丙孕酮是17-羟孕酮的合成衍生物，作为雄激素受体拮抗剂以及弱孕酮受体激动剂，具有弱的孕激素和糖皮质激素活性。 -
peptidoleukotrienes antagonist
RG-12525 is a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4, inhibiting LTC4-, LTD4- and LTE4-induced guinea pig parenchymal strips contractions, with IC50s of 2.6 nM, 2.5 nM and 7 nM, respectively. RG-12525 is also a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist with an IC50 of approximately 60 nM and a potent inhibitor of CYP3A4, with a Ki value of 0.5 µM.
