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CEP-32496 hydrochloride是野生型BRAF，V600E突变型BRAF和c-Raf的高效抑制剂，Kd值分别为14 nM，36 nM和39 nM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.05 mL | 90.27 mL | 180.53 mL |
| 0.5 mM | 3.61 mL | 18.05 mL | 36.11 mL |
| 1 mM | 1.81 mL | 9.03 mL | 18.05 mL |
| 5 mM | 0.36 mL | 1.81 mL | 3.61 mL |
*The above data is based on the productmolecular weight 553.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15040 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 553.92 |
| Formula | C24H23ClF3N5O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1227678-26-3 |
| Synonyms | CEP 32496 hydrochloride, CEP32496 hydrochloride |
| SMILES | CC(C)(C1=CC(=NO1)NC(=O)NC2=CC(=CC=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(F)(F)F.Cl |
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