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CEP-37440是一种新型的高效选择性FAK/ALK双重抑制剂，IC50为2.3 nM（FAK）和120 nM（ALK细胞在50％人血浆中的IC50。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.24 mL | 86.19 mL | 172.38 mL |
| 0.5 mM | 3.45 mL | 17.24 mL | 34.48 mL |
| 1 mM | 1.72 mL | 8.62 mL | 17.24 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.45 mL |
*The above data is based on the productmolecular weight 580.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15543 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 580.12 |
| Formula | C30H38ClN7O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1391712-60-9 |
| Synonyms | CEP37440, CEP 37440 |
| SMILES | CNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C4=C(CC(CCC4)N5CCN(CC5)CCO)C=C3)OC |
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