目录号
产品名
应用
产品描述
文献引用
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CFTR Inhibitor
奥利多宁(Isodonol),一种从红柴胡(Rabdosia rubescens)中分离出的环烷萜二萜,是一种重要的传统中药。 -
CFTR inhibitor
PTC124,也被称为Ataluren,是CFTR-G542X nonsense allele抑制剂。- L Kadunc, .et al. , FEBS Lett, 2020, May 13 PMID: 32401336
- Caspi M, .et al. , J Mol Med (Berl), 2016, Apr;94(4):469-82 PMID: 26620677
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CFTR activator
VX-770(Ivacaftor)被称为CFTR增效剂。- Daichi Hinata, .et al. , Int J Mol Sci, 2023, Jan 24;24(3):2305 PMID: 36768629
- Okiyoneda T, .et al. , Dev Cell, 2018, Mar 26;44(6):694-708.e7 PMID: 29503157
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CFTR modulator
VX-809 是第二个用于治疗囊性纤维化(CF)的口服候选化合物。- Danny D Dinh, .et al. , EBioMedicine, 2024, Apr:102:105058 PMID: 38490104
- Daichi Hinata, .et al. , Int J Mol Sci, 2023, Jan 24;24(3):2305 PMID: 36768629
- Kusumika Saha, .et al. , Cell Mol Life Sci, 2022, Sep 27;79(10):530 PMID: 36167862
- Heledd H Jarosz-Griffiths, .et al. , Elife, 2020, Mar 2;9:e54556 PMID: 32118580
- Okiyoneda T, .et al. , Dev Cell, 2018, Mar 26;44(6):694-708.e7 PMID: 29503157
- Junko Kido, .et al. , Infect Immun, 2017, Oct; 85(10): e00311-17 PMID: 28784926
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CFTR corrector
VX-661 是另一种正在开发中的囊性纤维化跨膜传导调节因子(cystic fibrosis transmembrane conductance regulator, CFTR)校正剂,用于治疗囊性纤维化。- Daichi Hinata, .et al. , Int J Mol Sci, 2023, Jan 24;24(3):2305 PMID: 36768629
- Kusumika Saha, .et al. , Cell Mol Life Sci, 2022, Sep 27;79(10):530 PMID: 36167862
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CFTR inhibitor
CFTRinh-172 是一种电压独立的、选择性的 CFTR 抑制剂。- Dao-Lai Zhang, .et al. , eLife, 2018, 7: e33432 PMID: 29393851
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CFTR inhibitor
CFTR 抑制剂 II,亦称为 GlyH-101,是一种甘氨酸肼,能够选择性且可逆地阻断 CFTR 通道(Ki = 4.3 uM)。- Dao-Lai Zhang, .et al. , eLife, 2018, 7: e33432 PMID: 29393851
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CFTR corrector
CFTR corrector 2 是一种囊性纤维化跨膜传导调节剂(CFTR),从美国专利 US20140274933 中提取。 -
anticancer agent
5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP), a renowned medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein. 5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration-dependent manner.