微信关注
Total item
Cart Subtotal
￥ 0.00 Chk
| Catalog No. | Inhibitor Name | Chk1 | Chk2 | Other |
|---|---|---|---|---|
| A10113 | AZD7762 | *** | ||
| A11036 | LY2603618 | *** | ||
| A11167 | MK-8776 | *** | * | CDK2 |
| A11046 | CHIR-124 | **** | * | FLT3,PDGFR,GSK-3 |
| A11520 | PF-477736 | **** | ** | VEGFR2,Fms,YES |
| A11108 | CCT241533 | **** | ||
| A13575 | BML-277 | *** | ||
| A15480 | SB 218078 | *** | cdc2, PKC | |
| A15550 | CCT244747 | ** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
38 个项目
每页
-
TAK-960 hydrochloride
Catalog No. A21703 PLK1 inhibitorTAK-960 hydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM at 10 μM ATP; TAK-960 hydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. 了解更多 -
GDC-0575 dihydrochloride
Catalog No. A21567 CHK1 inhibitorGDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity. 了解更多 -
Centrinone
Catalog No. A20858 PLK4 inhibitorCentrinone (LCR-263) is a selective and reversible inhibitor of polo-like kinase 4 (PLK4) with a Ki of 0.16 nM. 了解更多 -
Centrinone-B
Catalog No. A20855 PLK4 inhibitorCentrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor, with a Ki of 0.59 nM. 了解更多 -
AAPK-25
Catalog No. A19085 Aurora/PLK dual 抑制剂AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. 了解更多 -
CCT244747
Catalog No. A15550 -
CCT241533 hydrochloride
Catalog No. A15038 Chk2 抑制剂CCT241533 hydrochloride是一种有效的丝氨酸/苏氨酸检查点激酶（Chk2）抑制剂，IC50为3 nM；显示在1 uM下与一组激酶的交叉反应最小。 了解更多 -
SBE 13 HCl
Catalog No. A14426 PLK 抑制剂SBE 13 HCl是PLK1的选择性抑制剂，对于PLK1，PLK3和PLK2，IC 50值分别为200pM，875nM和66μM。 了解更多 -
NMS-1286937
Catalog No. A13045 -
LY2603618 (IC-83)
Catalog No. A11036 Chk 抑制剂LY2603618 (IC-83)是一种chk2抑制剂，可与chk2结合并抑制其活性，这可能会阻止DNA损伤剂引起的DNA修复。 了解更多 -
HMN-214
Catalog No. A10452 -
TAK-960
Catalog No. A11146 -
BI6727 (Volasertib)
Catalog No. A10135 PLK 抑制剂BI6727 (Volasertib)是一种高效且选择性的polo样激酶（PLK）1抑制剂（在一组癌细胞系中，酶IC50 = 0.87 nM，EC50 = 11-37 nM）。 了解更多 -
SCH 900776 (MK-8776)
Catalog No. A11167 Chk1 抑制剂SCH 900776 (MK-8776)是靶向细胞周期检查点激酶1（Chk1）的药物，无细胞试验中IC50为3 nM，比作用于Chk2选择性高500倍。具有潜在的放射增敏和化学增敏活性。 了解更多 -
ON-01910 (rigosertib)
Catalog No. A10673 PLK 抑制剂ON-01910 (rigosertib)通过涉及PI3K/AKT抑制和氧化应激诱导的双重作用机制对慢性淋巴细胞白血病细胞具有选择性的细胞毒性。 了解更多 -
MLN 0905
Catalog No. A12429 -
PF 477736
Catalog No. A11520 -
PD0166285
Catalog No. A15863 -
GDC-0575 (ARRY-575, RG7741)
Catalog No. A16811 -
LY2606368
Catalog No. A13684 -
SCH900776 (S-isomer)
Catalog No. A12703 CHK1 抑制剂SCH900776 (S-isomer)是靶向细胞周期检查点激酶1（Chk1）抑制剂，无细胞试验中IC50为3 nM，比作用于Chk2选择性高500倍。具有潜在的放射增敏和化学增敏活性。 了解更多 -
BML-277
Catalog No. A13575 -
CHIR-124
Catalog No. A11046 -
AZD7762
Catalog No. A10113
38 个项目
每页