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CHF5074是新型的γ-分泌酶调节剂，可减少Aβ42和Aβ40的分泌，IC50分别为3.6和18.4 uM。
| In vitro | DMSO | 51 mg/mL (156.84 mM) | |
| Water | Insoluble | ||
| Ethanol | 8 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.75 mL | 153.77 mL | 307.54 mL |
| 0.5 mM | 6.15 mL | 30.75 mL | 61.51 mL |
| 1 mM | 3.08 mL | 15.38 mL | 30.75 mL |
| 5 mM | 0.62 mL | 3.08 mL | 6.15 mL |
*The above data is based on the productmolecular weight 325.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16214 |
|---|---|
| 作用机制 | Modulator (调节剂) |
| M. Wt | 325.16 |
| Formula | C16H11Cl2FO2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 749269-83-8 |
| Synonyms | CSP-1103, CHF-5074 |
| SMILES | O=C(C1(C2=CC=C(C3=CC=C(Cl)C(Cl)=C3)C(F)=C2)CC1)O |
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