CHIR-99021 monohydrochloride

Name: CHIR-99021 monohydrochloride
SKU: A21430
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A21430

GSK-3α/β 抑制剂

CHIR-99021 一水盐酸盐（CT99021 一水盐酸盐）是一种 GSK-3α/β 抑制剂，其 IC50 值分别为 10 nM/6.7 nM；对 GSK-3 与其最接近的同源物 CDC2 和 ERK2 以及其他蛋白激酶具有超过 500 倍的选择性。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
2mg	¥245.00	现货
5mg	¥455.00	现货
10mg	¥630.00	现货
25mg	¥1,120.00	现货
50mg	¥1,715.00	现货
100mg	¥3,395.00	现货
200mg	¥4,935.00	现货
500mg	¥7,525.00	现货
*10mM 1mL in DMSO**	¥490.00	现货
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Data Sheet

SDS

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生物活性

Discription

CHIR-99021 monohydrochloride (CT99021 monohydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases.

Targets

Target	Value

产品信息

目录号	A21430
分子式	C22H19Cl3N8
分子量	501.8
CAS号	1797989-42-4
SMILES	N#CC1=CC=C(NCCNC2=NC=C(C3=NC=C(C)N3)C(C4=CC=C(Cl)C=C4Cl)=N2)N=C1.[H]Cl
其他名称	CHIR99021, CHIR 99021, CT99021 monohydrochloride, CT 99021, CT-99021
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	89 mg/mL (177.36 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (3.98 mM)
In vivo	5% DMSO+30% PEG 300+ddH2O	22 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.93 mL	99.64 mL	199.28 mL
0.5 mM	3.99 mL	19.93 mL	39.86 mL
1 mM	1.99 mL	9.96 mL	19.93 mL
5 mM	0.4 mL	1.99 mL	3.99 mL

Useful Calculator

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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