Laduviglusib (CHIR-99021)

Name: Laduviglusib (CHIR-99021)
SKU: A10199
Price: 210 CNY
Rating: 5 (13 reviews)

目录号: A10199

GSK-3 抑制剂

13 篇发表文献

CHIR99021 是一种氨基嘧啶衍生物，能够抑制 GSK3α 和 GSK3β，其 IC50 值分别为 10 nM 和 6.7 nM。

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Grouped product items
规格	价格	库存
2mg	¥210.00	现货
5mg	¥350.00	现货
10mg	¥560.00	现货
25mg	¥1,085.00	现货
50mg	¥1,820.00	现货
100mg	¥2,940.00	现货
200mg	¥4,410.00	现货
500mg	¥6,860.00	现货
*10mM 1mL in DMSO**	¥385.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Laduviglusib (CHIR-99021)发表的13篇文献

Peilin Li, .et al. , Ecotoxicol Environ Saf, 2024, Dec:288:117330 PMID: 39571255

Peilin Li, .et al. , Stem Cell Res Ther, 2024, Aug 26;15(1):269 PMID: 39183353

Andreea Manole, .et al. , Cell Rep, 2023, Dec 26;42(12):113466 PMID: 38039131

Claudia Z Han, .et al. , Immunity, 2023, Sep 12;56(9):2152-2171 PMID: 37582369

Eric Lian, .et al. , STAR Protoc, 2023, May 22;4(2):102314 PMID: 37220001

Tomoki Murata, .et al. , Int Immunol, 2023, Apr 13 PMID: 37052267

Shunsuke Murakami, .et al. , Regen Ther, 2022, Nov 25;21:574-583 PMID: 36475025

Adam Pietrobon, .et al. , Cell Rep, 2022, Jul 5;40(1):111048 PMID: 35793620

Takayuki Miyoshi, .et al. , J Gastroenterol, 2022, Jun;57(6):441-452 PMID: 35294680

Tomoki Kamatani, .et al. , Inflamm Regen, 2022, Feb 2;42(1):4 PMID: 35105370

Dan Zhao, .et al. , Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046

Otsuka R, .et al. , Sci Rep, 2020, Jan 14;10(1):224 PMID: 31937817

Yu Huang, .et al. , Stem Cells Int, 2019, 2019: 3975689 PMID: 31565060

生物活性

Discription

CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10199
分子式	C22H18Cl2N8
分子量	465.3
CAS号	252917-06-9
SMILES	CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
其他名称	GSK-3 Inhibitor XVI, CT 99021
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	Warmed: 9 mg/mL (19.33 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+ddH2O	3.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.49 mL	107.46 mL	214.92 mL
0.5 mM	4.3 mL	21.49 mL	42.98 mL
1 mM	2.15 mL	10.75 mL	21.49 mL
5 mM	0.43 mL	2.15 mL	4.3 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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