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Cilomilast (SB-207499)可作为选择性磷酸二酯酶4抑制剂，具有抗炎作用。可针对与COPD相关的支气管收缩，粘液分泌过多和气道重塑。
靶点信息
| In vitro (25°C) | DMSO | 64 mg/mL (186.36 mM) | |
| Water | Insoluble | ||
| Ethanol | 47 mg/mL (136.85 mM) | ||
| In vivo | 5% DMSO+95% Corn oil | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.12 mL | 145.6 mL | 291.21 mL |
| 0.5 mM | 5.82 mL | 29.12 mL | 58.24 mL |
| 1 mM | 2.91 mL | 14.56 mL | 29.12 mL |
| 5 mM | 0.58 mL | 2.91 mL | 5.82 mL |
*The above data is based on the productmolecular weight 343.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10216 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 343.4 |
| Formula | C20H25NO4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 153259-65-5 |
| Synonyms | SB207499, Ariflo, SB-207,499 |
| SMILES | COC1=C(C=C(C=C1)C2(CCC(CC2)C(=O)O)C#N)OC3CCCC3 |
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