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CL2 Linker

CL2 Linker

Name: CL2 Linker
SKU: A18388

目录号: A18388

cleavable ADC linker

CL2 Linker Chemical Structure

CAS NO. 2270986-66-6

CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours).

库存：现货

规格	价格	数量
1 mg	￥ 2,240.00
5 mg	￥ 6,720.00
10 mg	￥ 11,200.00

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	7.01 mL	35.05 mL	70.1 mL
0.5 mM	1.4 mL	7.01 mL	14.02 mL
1 mM	0.7 mL	3.5 mL	7.01 mL
5 mM	0.14 mL	0.7 mL	1.4 mL

*The above data is based on the productmolecular weight 1426.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A18388
M. Wt	1426.61
Formula	C68H103N11O22
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	2270986-66-6
SMILES	OCC(COC(N(C)CCN(C)C(OCC(C=C1)=CC=C1NC([C@H](CCCCNC(OC(C)(C)C)=O)NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCN2C=C(CNC(CCCCCN3C(C=CC3=O)=O)=O)N=N2)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O