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CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 6.75 mL | 33.77 mL | 67.54 mL |
| 0.5 mM | 1.35 mL | 6.75 mL | 13.51 mL |
| 1 mM | 0.68 mL | 3.38 mL | 6.75 mL |
| 5 mM | 0.14 mL | 0.68 mL | 1.35 mL |
*The above data is based on the productmolecular weight 1480.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18392 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 1480.61 |
| Formula | C73H97N11O22 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1279680-68-0 |
| SMILES | O=C(O[C@](C1=C(CO2)C(N3CC4=C(CC)C5=CC(O)=CC=C5N=C4C3=C1)=O)(CC)C2=O)OCC6=CC=C(NC([C@H](CCCCN)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN7N=NC(CNC(C8CCC(CN9C(C=CC9=O)=O)CC8)=O)=C7)=O)=O)=O)C=C6 |
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