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L2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 9.04 mL | 45.2 mL | 90.4 mL |
| 0.5 mM | 1.81 mL | 9.04 mL | 18.08 mL |
| 1 mM | 0.9 mL | 4.52 mL | 9.04 mL |
| 5 mM | 0.18 mL | 0.9 mL | 1.81 mL |
*The above data is based on the productmolecular weight 1106.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18396 |
|---|---|
| M. Wt | 1106.22 |
| Formula | C51H79N9O18 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1846605-04-6 |
| SMILES | O=C(NC1=CC=C(COC(O)=O)C=C1)[C@H](CCCCN)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN2N=NC(CNC(C3CCC(CN4C(C=CC4=O)=O)CC3)=O)=C2)=O)=O |
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