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Cladribine是一种腺苷脱氨酶抑制剂，从而干扰细胞处理DNA的能力。
靶点信息
| Adenosine deaminase (MM1.S cells) | Adenosine deaminase (RPMI8226 cells) | Adenosine deaminase (U266 cells) | ||
| 0.18 μM | 0.75 μM | 2.43 μM |
| In vitro (25°C) | DMSO | 52 mg/mL (182.01 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+30% PEG 300+1% Tween 80+H2O | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35 mL | 175.01 mL | 350.02 mL |
| 0.5 mM | 7 mL | 35 mL | 70 mL |
| 1 mM | 3.5 mL | 17.5 mL | 35 mL |
| 5 mM | 0.7 mL | 3.5 mL | 7 mL |
*The above data is based on the productmolecular weight 285.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10223 |
|---|---|
| M. Wt | 285.7 |
| Formula | C10H12ClN5O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 4291-63-8 |
| Synonyms | 2-chlorodeoxyadenosine, Leustatin |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(N=C3N)Cl)CO)O |
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