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Col003 is a potent inhibitor of Hsp47, competitively binds to the collagen binding site on Hsp47 (IC50, 1.8 μM), and inhibits collagen secretion by destabilizing the collagen triple helix.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 38.87 mL | 194.37 mL | 388.74 mL |
| 0.5 mM | 7.77 mL | 38.87 mL | 77.75 mL |
| 1 mM | 3.89 mL | 19.44 mL | 38.87 mL |
| 5 mM | 0.78 mL | 3.89 mL | 7.77 mL |
*The above data is based on the productmolecular weight 257.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18573 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 257.24 |
| Formula | C14H11NO4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 328565-16-8 |
| Synonyms | Col 003, Col-003 |
| SMILES | O=CC1=CC(CC2=CC=CC=C2)=CC([N+]([O-])=O)=C1O |
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