Compound 401

Name: Compound 401
SKU: A11778

目录号: A11778

DNA-PK 抑制剂

Compound 401 Chemical Structure

CAS NO. 168425-64-7

Compound 401是一种细胞可渗透的嘧啶-异喹啉酮化合物，可作为有效的，可逆的和ATP竞争的DNA-PK抑制剂（IC50 = 280 nM），选择性是mTOR（IC50 = 5.3μM）的19倍。

库存：现货

规格	价格	数量
10 mg	￥ 875.00
25 mg	￥ 2,100.00
50 mg	￥ 3,220.00

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生物活性

Compound 401是一种细胞可渗透的嘧啶-异喹啉酮化合物，可作为有效的，可逆的和ATP竞争的DNA-PK抑制剂（IC50 = 280 nM），选择性是mTOR（IC50 = 5.3μM）的19倍。

溶解度 *

In vitro	DMSO	7 mg/mL (24.88 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.55 mL	177.74 mL	355.48 mL
0.5 mM	7.11 mL	35.55 mL	71.1 mL
1 mM	3.55 mL	17.77 mL	35.55 mL
5 mM	0.71 mL	3.55 mL	7.11 mL

*The above data is based on the productmolecular weight 281.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11778
作用机制	Inhibitor (抑制剂)
M. Wt	281.31
Formula	C16H15N3O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	168425-64-7
SMILES	C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2