Compstatin

目录号: A22732

Primates' C3 Inhibitor

Compstatin,一种13个氨基酸残基的环状肽,是一种针对补体系统C3的强效抑制剂,具有物种特异性。Compstatin与狒狒的C3结合,并且在狒狒血液中(与人类相似)具有抗蛋白酶切割的特性。Compstatin仅抑制灵长类动物的补体系统激活。Compstatin的IC50值分别为63微摩尔和12微摩尔,针对经典和替代补体途径。
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规格 价格 库存 数量
500µg
¥350.00
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1mg
¥455.00
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5mg
¥1,190.00
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10mg
¥1,855.00
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25mg
¥3,150.00
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50mg
¥4,585.00
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100mg
¥6,440.00
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Discription

Compstatin, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin inhibits only the activation of primates' complement system. Compstatin exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively.

产品信息
目录号 A22732
分子式 C66H99N23O17S2
分子量 1550.77
CAS号 206645-99-0
Sequence Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys12)
Sequence shortening ICVVQDWGHHRCT-NH2 (Disulfide bridge: Cys2-Cys12)
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