COTI-2
目录号: A16974
COTI-2 是一种可口服的硫代脒，能激活 p53 的突变形式。它能在多种人类肿瘤细胞培养中诱导凋亡，抑制结直肠癌细胞系的增殖，并且在纳摩尔浓度下对人类胶质母细胞瘤细胞系具有活性。
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生物活性
| Discription | COTI-2 is an orally available thiosemicarbazone that activates mutant forms of p53. It induces apoptosis in a wide variety of human tumor cells in culture, inhibits the proliferation of colorectal cancer cell lines, and is active against human glioblastoma cell lines at nanomolar concentrations. |
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产品信息
| 目录号 | A16974 |
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| 分子式 | C19H22N6S |
| 分子量 | 366.5 |
| CAS号 | 1039455-84-9 |
| SMILES | S=C(N/N=C1C(N=CC=C2)=C2CCC\1)N(CC3)CCN3C4=NC=CC=C4 |
| 其他名称 | COTI2, COTI 2 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 69 mg/mL (188.28 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.29 mL | 136.43 mL | 272.85 mL |
| 0.5 mM | 5.46 mL | 27.29 mL | 54.57 mL |
| 1 mM | 2.73 mL | 13.64 mL | 27.29 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1039455-84-9 | 1039455-84-9 供应商 | 1039455-84-9 花费 | 1039455-84-9 生产商 | 订购 1039455-84-9 | 1039455-84-9 代理商