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COTI-2是一种口服的硫代半胱氨酸，可激活p53的突变形式。它在培养的多种人类肿瘤细胞中诱导凋亡，抑制结直肠癌细胞系的增殖，并在纳摩尔浓度下对人类胶质母细胞瘤细胞系具有活性。
| In vitro | DMSO | 69 mg/mL (188.28 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.29 mL | 136.43 mL | 272.85 mL |
| 0.5 mM | 5.46 mL | 27.29 mL | 54.57 mL |
| 1 mM | 2.73 mL | 13.64 mL | 27.29 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
*The above data is based on the productmolecular weight 366.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16974 |
|---|---|
| M. Wt | 366.5 |
| Formula | C19H22N6S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1039455-84-9 |
| Synonyms | COTI2, COTI 2 |
| SMILES | S=C(N/N=C1C(N=CC=C2)=C2CCC\1)N(CC3)CCN3C4=NC=CC=C4 |
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