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CP-690550 (Tofacitinib citrate)

CP-690550 (Tofacitinib citrate)

Name: CP-690550 (Tofacitinib citrate)
SKU: A10241

目录号: A10241

JAK3 抑制剂

Product Citations (1)

CP-690550 (Tofacitinib citrate) Chemical Structure

CAS NO. 540737-29-9

CP-690550 (Tofacitinib citrate)是口服的高选择性Janus激酶（JAK）酶抑制剂。

库存：现货

规格	价格	数量
10 mg	￥ 280.00
50 mg	￥ 630.00
100 mg	￥ 840.00
10mM * 1mL in DMSO	￥ 420.00

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生物活性

CP-690550 (Tofacitinib citrate)是口服的高选择性Janus激酶（JAK）酶抑制剂。

Targets

Target	Value
JAK3	IC50: 1nM
JAK2	IC50: 20nM
JAK1	IC50: 112nM
ROCK2	IC50: 3.4μM
LCK	IC50: 3.87μM
IRK	IC50: >10μM
CDK2	IC50: >10μM
CDK5	IC50: >10μM
EGFR	IC50: >10μM
MAPK2/ERK2	IC50: >10μM
JNK1/SAPK1c	IC50: >10μM
SAPK2a/p38	IC50: >10μM
SAPK2b/p38b2	IC50: >10μM
SAPK3/p38g	IC50: >10μM
SAPK4/p38d	IC50: >10μM
MAPKAPK2	IC50: >10μM
MAPKAP-K1b	IC50: >10μM
MSK1	IC50: >10μM
PRAK	IC50: >10μM
PKA	IC50: >10μM
PKCα	IC50: >10μM
PDK-1	IC50: >10μM
PKBα	IC50: >10μM
SGK	IC50: >10μM
p70S6K	IC50: >10μM
GSK-3β	IC50: >10μM
AMPK	IC50: >10μM
Chk1	IC50: >10μM
CK2	IC50: >10μM
PHK	IC50: >10μM
CSK	IC50: >10μM
CDK2/CyclinA	IC50: >10μM
PI3K	IC50: >10μM

溶解度 *

In vitro (25°C)	DMSO	Warmed: 94 mg/mL (186.32 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% methylcellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.82 mL	99.11 mL	198.22 mL
0.5 mM	3.96 mL	19.82 mL	39.64 mL
1 mM	1.98 mL	9.91 mL	19.82 mL
5 mM	0.4 mL	1.98 mL	3.96 mL

*The above data is based on the productmolecular weight 504.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10241
作用机制	Inhibitor (抑制剂)
M. Wt	504.5
Formula	C16H20N6O.C6H8O7
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	540737-29-9
Synonyms	CP690550, tasocitinib citrate, CP-690,550
SMILES	C[C@@H]1CCN(C[C@@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O