产品详情

生物活性

CPI-169是一种有效的选择性EZH2抑制剂，对EZH2 WT，EZH2 Y641N和EZH1的IC50分别为0.24 nM，0.51 nM和6.1 nM。

靶点信息

EZH2 WT	EZH2 Y641N	EZH1
0.24 nM	0.51 nM	6.1 nM

溶解度 *

In vitro (25°C)	DMSO	88 mg/mL (166.45 mM)
	Water	Insoluble
	Ethanol	88 mg/mL (166.45 mM)
In vivo	10% DMSO+60% PEG 400+30% ddH2O	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.92 mL	94.58 mL	189.16 mL
0.5 mM	3.78 mL	18.92 mL	37.83 mL
1 mM	1.89 mL	9.46 mL	18.92 mL
5 mM	0.38 mL	1.89 mL	3.78 mL

*The above data is based on the productmolecular weight 528.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A15920
作用机制	Inhibitor (抑制剂)
M. Wt	528.66
Formula	C27H36N4O5S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1450655-76-1
Synonyms	CPI 169, CPI169
SMILES	CCS(N1CCC([C@@](N2C(C)=C(/C(O)=N/CC(C(O)=N3)=C(OC)C=C3C)C4=CC=CC=C42)([H])C)CC1)(=O)=O