CPI-360
目录号: A15908
EZH2 抑制剂
CPI-360 是一种选择性的 EZH2 抑制剂,其对野生型 EZH2 和 Y641N 突变型 EZH2 的 IC50 值分别为 0.5 nM 和 2.5 nM。
Discription | CPI-360 is a selective EZH2 inhibitor with IC50 values of 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2, respectively. | ||
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Targets |
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目录号 | A15908 |
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分子式 | C25H31N3O4 |
分子量 | 437.53 |
CAS号 | 1802175-06-9 |
SMILES | CC(N1)=CC(OC)=C(CNC(C2=C(C)N([C@H](C)C3CCOCC3)C4=C2C=CC=C4)=O)C1=O |
其他名称 | CPI360, CPI 360 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro (25°C) | DMSO | Warmed: 18 mg/mL (41.14 mM) | |
Water | Insoluble | ||
Ethanol | Warmed: 16 mg/mL (36.57 mM) | ||
In vivo | 10% DMSO+60% PEG 400+ddH2O | 19 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 22.86 mL | 114.28 mL | 228.56 mL |
0.5 mM | 4.57 mL | 22.86 mL | 45.71 mL |
1 mM | 2.29 mL | 11.43 mL | 22.86 mL |
5 mM | 0.46 mL | 2.29 mL | 4.57 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2