微信关注
Total item
Cart Subtotal
￥ 0.00 产品详情
Crenolanib (CP-868596)是口服生物可用的PDGFR酪氨酸激酶的选择性小分子抑制剂，在皮摩尔浓度下抑制PDGFRA和PDGFRB。
靶点信息
| PDGFRα (CHO cells) | PDGFRβ (CHO cells) | FLT3 | ||
| 2.1 nM(Kd) | 3.2 nM(Kd) | 0.74 nM (Kd) |
| In vitro (25°C) | DMSO | Warmed: 84 mg/mL (189.38 mM) | |
| Water | Insoluble | ||
| Ethanol | 7 mg/mL (15.78 mM) | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.55 mL | 112.74 mL | 225.48 mL |
| 0.5 mM | 4.51 mL | 22.55 mL | 45.1 mL |
| 1 mM | 2.25 mL | 11.27 mL | 22.55 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.51 mL |
*The above data is based on the productmolecular weight 443.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11052 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 443.5 |
| Formula | C26H29N5O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 670220-88-9 |
| Synonyms | CP868596, CP 868596 |
| SMILES | CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4 |
产品资料
产品标签
Product Questions
Product Questions
No Questions
您还可能对下列产品感兴趣
Masitinib mesylate
Masitinib mesylate是Kit和PDGFRα/β的新型抑制剂，IC50为200 nM和540 nM/800 nM，对ABL和c-Fms的抑制作用较弱。
Regorafenib (BAY 73-4506)
Regorafenib (BAY 73-4506)是一种多激酶抑制剂，IC50为17、40和69 nM c-KIT，VEGFR2，B-Raf。Regorafenib（BAY 73-4506）是一种…
Flumatinib mesylate
Flumatinib mesylate以时间和剂量依赖性的方式降低U266细胞中C-MYC，HIF-1a和VEGF的表达，因此甲磺酸氟马替尼可能…
Pazopanib HCl (GW786034)
Pazopanib HCl (GW786034)是VEGFR-1，VEGFR-2，VEGFR-3，PDGFR-a/β和c-kit的有效且选择性的多靶点酪氨酸激酶抑制剂，可…
Toceranib (PHA 291639, SU 11654)
Toceranib (PHA 291639,SU 11654)是一种激酶抑制剂，通过抑制KIT，血管内皮生长因子受体2和PDGFRβ同时具有抗肿瘤…
AC710 Mesylate
AC710 Mesylate是一种有效的选择性PDGFR家族激酶抑制剂，对于FLT3/KIT/PDGFRα/PDGFRβ的Kd值分别为0.6 nM/1.0 nM/1.3 nM/1.…
Linifanib (ABT-869)
Linifanib (ABT-869)是一种结构新颖的有效RTK，VEGF和PDGF抑制剂，对人内皮细胞，PDGFR-β，KDR和CSF-1R的IC50分别为0.…
Keywords:购买 Crenolanib (CP-868596) | Crenolanib (CP-868596) 供应商 | 订购 Crenolanib (CP-868596) | Crenolanib (CP-868596) 价格 | Crenolanib (CP-868596) 生产商 | 订单 Crenolanib (CP-868596) | Crenolanib (CP-868596) 代理商 | 购买 670220-88-9| 670220-88-9 供应商 | 订购 670220-88-9 | 670220-88-9 价格 | 670220-88-9 生产商 | 订单 670220-88-9 | 670220-88-9 代理商|buy Crenolanib (CP-868596) | Crenolanib (CP-868596) Supplier | purchase Crenolanib (CP-868596) | Crenolanib (CP-868596) cost | Crenolanib (CP-868596) manufacturer | order Crenolanib (CP-868596) | Crenolanib (CP-868596) distributor | buy 670220-88-9| 670220-88-9 Supplier | purchase 670220-88-9 | 670220-88-9 cost | 670220-88-9 manufacturer | order 670220-88-9 | 670220-88-9 distributor