Crenolanib (CP-868596)

Name: Crenolanib (CP-868596)
SKU: A11052
Price: 280 CNY
Rating: 5 (1 reviews)

目录号: A11052

PDGFR/FLT3 抑制剂

1 篇发表文献

Crenolanib (CP-868596) 是一种口服生物利用度高的选择性小分子抑制剂，针对 PDGFR 酪氨酸激酶 进行抑制，能在皮克摩尔浓度下同时抑制 PDGFRA 和 PDGFRB。

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Grouped product items
规格	价格	库存
1mg	¥280.00	现货
2mg	¥315.00	现货
5mg	¥490.00	现货
10mg	¥805.00	现货
25mg	¥1,330.00	现货
50mg	¥1,785.00	现货
100mg	¥3,115.00	现货
*10mM 1mL in DMSO**	¥560.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Crenolanib (CP-868596)发表的1篇文献

N Naganna, .et al. , EBioMedicine, 2019, Jan 24. pii: S2352-3964(19)30012-X PMID: 30686755

生物活性

Discription

Crenolanib (CP-868596) is an orally bioavailable, selective small molecule inhibitor of the PDGFR tyrosine kinase, inhibiting both PDGFRA and PDGFRB at picomolar concentrations.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11052
分子式	C26H29N5O2
分子量	443.5
CAS号	670220-88-9
SMILES	CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4
其他名称	CP868596, CP 868596
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	Warmed: 84 mg/mL (189.38 mM)
	Water	Insoluble
	Ethanol	7 mg/mL (15.78 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.55 mL	112.74 mL	225.48 mL
0.5 mM	4.51 mL	22.55 mL	45.1 mL
1 mM	2.25 mL	11.27 mL	22.55 mL
5 mM	0.45 mL	2.25 mL	4.51 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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