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Cryptotanshinone

Cryptotanshinone

Name: Cryptotanshinone
SKU: A10244

目录号: A10244

Stat3 抑制剂

Cryptotanshinone Chemical Structure

CAS NO. 35825-57-1

Cryptotanshinone是一种STAT3抑制剂，在DU145细胞中能显着阻断STAT3 Tyr705磷酸化，但不能阻断STAT3 Ser727磷酸化，并显着抑制JAK2磷酸化，IC50为?5μM，而不影响上游激酶c的磷酸化。

库存：现货

规格	价格	数量
10 mg	￥ 280.00
25 mg	￥ 630.00
50 mg	￥ 1,190.00

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产品详情

生物活性

靶点信息

STAT3 (HCT-116 cells)
4.6 μM

溶解度 *

In vitro (25°C)	DMSO	Warmed: 5 mg/mL (16.87 mM)
	Water	Insoluble
	Ethanol	Warmed: 1 mg/mL (3.37 mM)
In vivo	5% DMSO+40%PEG 300+5% Tween80 +ddH2O	1.18 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	33.74 mL	168.69 mL	337.38 mL
0.5 mM	6.75 mL	33.74 mL	67.48 mL
1 mM	3.37 mL	16.87 mL	33.74 mL
5 mM	0.67 mL	3.37 mL	6.75 mL

*The above data is based on the productmolecular weight 296.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10244
作用机制	Inhibitor (抑制剂)
M. Wt	296.4
Formula	C19H20O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	35825-57-1
Synonyms	Tanshinone
SMILES	C[C@H]1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C