CX-4945 (Silmitasertib)

Name: CX-4945 (Silmitasertib)
SKU: A11060
Price: 175 CNY
Rating: 5 (15 reviews)

目录号: A11060

CK2 抑制剂

15 篇发表文献

CX-4945 是一种有效且选择性的口服生物利用度高的小分子抑制剂，专门针对 CK2，能够抑制人类脐静脉内皮细胞迁移、管状形成，并阻断 CK2-依赖的癌细胞中低氧诱导因子 1 alpha (HIF-1α) 的转录。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
2mg	¥245.00	现货
5mg	¥490.00	现货
10mg	¥840.00	现货
25mg	¥1,470.00	现货
50mg	¥2,380.00	现货
100mg	¥3,780.00	现货
500mg	¥8,155.00	现货
*10mM 1mL in DMSO**	¥560.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用CX-4945 (Silmitasertib)发表的15篇文献

Michael Ohene-Nyako, .et al. , ASN Neuro, 2023, Jan-Dec;15:17590914231158218 PMID: 36890725

Wenjie Huang, .et al. , Am J Pathol, 2023, May;193(5):567-578 PMID: 37080661

Xixi Zhao, .et al. , Cancer Res, 2022, Jun 6;82(11):2185-2195 PMID: 35385574

Janeen H. Trembley, .et al. , Biomedicines, 2021, May; 9(5): 571 PMID: 34070147

Tianzhi Huang, .et al. , Mol Cell, 2021, Mar 18;81(6):1276-1291 PMID: 33539787

M Afzal, .et al. , Molecular and Cellular Biochemistry, 2020, 470, pages131-143

Zaman MS, .et al. , Biometals, 2019, Oct 3 PMID: 31583500

Fukumoto Y, .et al. , Biochem Biophys Res Commun, 2019, Sep 17;517(2):310-316 PMID: 31353086

Fukumoto Y, .et al. , Biochem Biophys Res Commun, 2018, Oct 2;504(2):380-386 PMID: 29902452

ST Ribeiro, .et al. , Leukemia, 2017, Jul; 31(7): 1603-1610 PMID: 27899804

Valentina Gandin, .et al. , Nat Commun, 2016, 7: 11127 PMID: 27040916

Ampofo E, .et al. , Eur Surg Res, 2016, 57(1-2):111-24 PMID: 27287005

Emmanuel Ampofo, .et al. , Thromb Res., 2015, Nov;136(5):996-1006 PMID: 26381437

Emmanuel Ampofo, .et al. , Biochim Biophys Acta., 2015, Oct;1852(10 Pt A):2123-36 PMID: 26189586

A. Margarida Gomes, .et al. , Haematologica, 2014, 99(6): 1062-1068 PMID: 24561792

生物活性

Discription

CX-4945 is a potent and selective orally bioavailable small molecule inhibitor of CK2 that inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11060
分子式	C19H12ClN3O2
分子量	349.8
CAS号	1009820-21-6
SMILES	C1=CC(=CC(=C1)Cl)NC2=C3C=CN=CC3=C4C=CC(=CC4=N2)C(=O)O
其他名称	Silmitasertib, CX 4945, CX4945
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	14 mg/mL (40.02 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% CMC Na	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.59 mL	142.94 mL	285.88 mL
0.5 mM	5.72 mL	28.59 mL	57.18 mL
1 mM	2.86 mL	14.29 mL	28.59 mL
5 mM	0.57 mL	2.86 mL	5.72 mL

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