CYC116
目录号: A10248
Aurora Kinase 抑制剂
Aurora kinase/VEGFR 2 抑制剂 CYC116 抑制 Aurora kinase A 和 B 以及 血管内皮生长因子受体 2 (VEGFR2)，导致细胞周期中断、快速细胞死亡以及抑制血管生成。
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生物活性
| Discription | Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. | |||||
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| Cell Research |
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产品信息
| 目录号 | A10248 |
|---|---|
| 分子式 | C18H20N6OS |
| 分子量 | 368.5 |
| CAS号 | 693228-63-6 |
| SMILES | CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | Warmed: 24 mg/mL (65.13 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.14 mL | 135.69 mL | 271.37 mL |
| 0.5 mM | 5.43 mL | 27.14 mL | 54.27 mL |
| 1 mM | 2.71 mL | 13.57 mL | 27.14 mL |
| 5 mM | 0.54 mL | 2.71 mL | 5.43 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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