Cyclopamine

Name: Cyclopamine
SKU: A10249

目录号: A10249

Hedgehog signaling 抑制剂

Cyclopamine Chemical Structure

CAS NO. 4449-51-8

Cyclopamine是一种特异性的Hedgehog (Hh)信号通路拮抗剂，作用于Smoothened (Smo)，IC50为46 nM。Cyclopamine 抑制Hedgehog信号通路， IC50 为46 nM。

库存：现货

规格	价格	数量
5 mg	￥ 315.00
10 mg	￥ 490.00
50 mg	￥ 1,050.00

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生物活性

Cyclopamine是一种特异性的Hedgehog (Hh)信号通路拮抗剂，作用于Smoothened (Smo)，IC50为46 nM。Cyclopamine 抑制Hedgehog信号通路， IC50 为46 nM。

靶点信息

Smoothened (TM3Hh12 cells)
46 nM

溶解度 *

In vitro	DMSO	Insoluble
	Water	DMF Warmed: 9 mg/mL (21.86 mM)
	Ethanol	Warmed: 2 mg/mL (4.85 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.3 mL	121.48 mL	242.95 mL
0.5 mM	4.86 mL	24.3 mL	48.59 mL
1 mM	2.43 mL	12.15 mL	24.3 mL
5 mM	0.49 mL	2.43 mL	4.86 mL

*The above data is based on the productmolecular weight 411.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10249
作用机制	Inhibitor (抑制剂)
M. Wt	411.6
Formula	C27H41NO2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	4449-51-8
Synonyms	11-deoxojervine
SMILES	C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5CC4=C3C)C)O)C)NC1