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￥ 0.00 Cytochrome P450
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Seviteronel
Catalog No. A20996 CYP17 lyase inhibitorSeviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition. 了解更多 -
Liarozole dihydrochloride
Catalog No. A21853 CYP450 dependent inhibitorLiarozole dihydrochloride (R75251; R85246) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase). 了解更多 -
CYP17-IN-1
Catalog No. A12622 CYP17 inhibitorCYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM. 了解更多 -
Sulfaphenazole
Catalog No. A17283 CYP2C9 inhibitorSulfaphenazole is a specific inhibitor of CYP2C9 which blocks atherogenic and pro-inflammatory effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. 了解更多 -
Efavirenz
Catalog No. A15826 -
Talarozole R enantiomer
Catalog No. A13113 Cytochrome P450 抑制剂Talarozole R enantiomer 通过阻断细胞色素P450酶同工酶CYP26（一种视黄酸羟化酶）来抑制视黄酸的代谢。 了解更多 -
Haloperidol (Haldol)
Catalog No. A10446 -
Clarithromycin
Catalog No. A10225 cytochrome P4503A4 抑制剂Clarithromycin是一种大环内酯类抗生素。它通过干扰细菌的蛋白质合成来防止细菌生长。 了解更多 -
Naringenin
Catalog No. A10625 Naringenin是一种黄烷酮，是一种类黄酮，被认为具有抗氧化剂，自由基清除剂，消炎，碳水化合物代谢促进剂和免疫系统调节剂等对人体健康的生物活性。 了解更多 -
Methoxsalen (Oxsoralen)
Catalog No. A10578 Methoxsalen (8-Methoxypsoralen)是一种有效的CYP三环呋喃香豆素自杀抑制剂（细胞色素P-450）。 了解更多 -
Hydroxyflutamide (Hydroxyniphtholide)
Catalog No. A11865 Hydroxyflutamide (Hydroxyniphtholide)是一种氟他胺的代谢产物，被发现可抑制雌二醇诱导的MCF-7乳腺癌细胞增殖。 了解更多 -
PF 4981517
Catalog No. A12544 CYP3A4 抑制剂PF 4981517是一种有效且选择性的CYP3A4抑制剂（CYP3A4，CYP3A5和CYP3A7的IC50值分别为0.03、17和70 μM）。 了解更多 -
Ozagrel(OKY-046)
Catalog No. A10688 -
3-Cyano-7-ethoxycoumarin
Catalog No. A13365 Fluorescent P450 substrate3-Cyano-7-ethoxycoumarin是适合连续测定细胞色素P450混合功能单加氧酶的荧光底物。它是用于微粒体脱烷基酶研究的荧光探针。 了解更多 -
Mephenytoin
Catalog No. A13366 -
Methoxyresorufin
Catalog No. A13367 -
TAK-700 Salt (Orteronel Salt)
Catalog No. A13515 CYP17A1/androgen synthesis 抑制剂TAK-700 Salt (Orteronel Salt)是一种雄激素合成抑制剂。它选择性地抑制在睾丸，肾上腺和前列腺肿瘤组织中表达的酶CYP17A。 了解更多 -
Choline Fenofibrate
Catalog No. A15044 -
Azathramycin
Catalog No. A15010 -
TH-302 (Evofosfamide)
Catalog No. A11144 TH-302 (Evofosfamide)是选择性靶向实体瘤缺氧激活的前体药物，靶向作用于实体瘤的hypoxic区域，IC50为19 nM，在缺氧条件下比在有氧条件下细胞毒性增强270倍，细胞色素P450代谢稳定。 了解更多 -
Benzbromarone
Catalog No. A16201 -
TOK-001 (Galeterone)
Catalog No. A11138 -
Avasimibe (CI-1011)
Catalog No. A10102 CYP17 抑制剂Avasimibe (CI-1011)是口服可生物利用的酰基辅酶A：胆固醇O-酰基转移酶（ACAT）抑制剂，IC50分别为2.9 μM， 13.9 μM和26.5 μM。 了解更多 -
Abiraterone Acetate (CB7630)
Catalog No. A11058 -
Abiraterone (CB-7598)
Catalog No. A10020 -
Voriconazole (Vfend)
Catalog No. A10978 -
TAK-700 (Orteronel)
Catalog No. A11044 -
Cyproterone acetate
Catalog No. A11409 Androgen Receptor 拮抗剂Cyproterone acetate是17-羟孕酮的合成衍生物，可作为雄激素受体拮抗剂以及具有弱孕激素和糖皮质激素活性的弱孕激素受体激动剂。 了解更多 -
Posaconazole
Catalog No. A10744 CYP3A4 抑制剂Posaconazole主要是CYP3A4的抑制剂，但不抑制其他CYP酶的活性。也是甾醇C14+脱甲基酶抑制剂的抑制剂，IC50为0.25μM。泊沙康唑的终末消除半衰期中位数为15-35小时。 了解更多 -
Ketoconazole
Catalog No. A10498 -
Itraconazole (Sporanox)
Catalog No. A10489 Itraconazole (Sporanox)是CYP3A4相对有效的抑制剂，IC50为6.1nM，用作三唑类抗真菌剂。 了解更多 -
Deferasirox
Catalog No. A10293 Iron chelatorDeferasirox是一种铁螯合剂，也是细胞色素P450 3A4诱导剂，细胞色素P450 2C8抑制剂和细胞色素P450 1A2抑制剂。 了解更多 -
Clotrimazole
Catalog No. A10234 clotrimazole的作用是对抗真菌的分裂和生长。clotrimazole改变真菌细胞壁的通透性并抑制细胞内酶的活性。 它特别抑制麦角固醇和细胞膜生产所需的其他固醇的生物合成。 了解更多 -
Cobicistat (GS-9350)
Catalog No. A11277 CYP3A 抑制剂Cobicistat (GS-9350)是有效，选择性的细胞色素酶P450 3A (CYP3A)抑制剂，包括重要的cyp3a4亚型。它还抑制肠道转运蛋白，增加几种hiv药物的整体吸收，包括atazanavir、darunavir和tenofovir alafenamide延胡索酸盐。 了解更多 -
Sodium Danshensu
Catalog No. A10853 Sodium danshensu是来自广泛使用的中草药丹参（丹参）的丹参素的钠盐。体外和体内研究表明，丹参素具有多种药理作用，包括舒张冠状动脉，抗凝，保护心肌缺血-再灌注损伤和抗心律不齐活动 了解更多
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