Dabrafenib (GSK2118436A)

Name: Dabrafenib (GSK2118436A)
SKU: A11381
Price: 245 CNY
Rating: 5 (8 reviews)

目录号: A11381

Raf 抑制剂

8 篇发表文献

Dabrafenib 是一种强效且选择性的 B-RAF 蛋白激酶 抑制剂，针对携带 V600E 突变，目前处于临床试验阶段。

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Grouped product items
规格	价格	库存
5mg	¥245.00	现货
10mg	¥350.00	现货
25mg	¥455.00	现货
50mg	¥560.00	现货
100mg	¥770.00	现货
200mg	¥1,050.00	现货
500mg	¥2,240.00	现货
1g	¥4,340.00	现货
*10mM 1mL in DMSO**	¥280.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Dabrafenib (GSK2118436A)发表的8篇文献

Rana Can Baygin, .et al. , Sci Rep, 2024, Jan 2;14(1):286 PMID: 38167959

Ali Talebi, .et al. , J Exp Clin Cancer Res, 2023, Apr 19;42(1):92 PMID: 37072838

Yuki Shimizu, .et al. , Cancer Lett, 2022, Sep 1;543 PMID: 35724767

Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812

Chenyang He, .et al. , Clinical and Translational Biophotonics, 2020, TTh3B.2

Hirosumi Tamura, .et al. , Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168

Brittany M. Duggan, .et al. , Sci Rep, 2017, 7: 1578 PMID: 28484277

Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

生物活性

Discription

Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11381
分子式	C23H20F3N5O2S2
分子量	519.6
CAS号	1195765-45-7
SMILES	CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F
其他名称	GSK2118436A
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	28 mg/mL (53.89 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+45% PEG 300+2% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.25 mL	96.23 mL	192.46 mL
0.5 mM	3.85 mL	19.25 mL	38.49 mL
1 mM	1.92 mL	9.62 mL	19.25 mL
5 mM	0.38 mL	1.92 mL	3.85 mL

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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