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Dabrafenib Mesylate

目录号: A15059

Raf 抑制剂

Dabrafenib Mesylate

Dabrafenib Mesylate Chemical Structure

CAS NO. 1195768-06-9

Dabrafenib Mesylate是一种新颖，有效和选择性的Raf激酶抑制剂，能够抑制野生型B-Raf，B-RafV600E和c-Raf的激酶活性，IC50值分别为3.2、0.8和5.0 nM。

库存： 现货

规格 价格 数量
10 mg
￥ 420.00
50 mg
￥ 630.00
100 mg
￥ 882.00
或
Warning 产品仅用于科学研究，不针对患者销售，望谅解.
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生物活性

Dabrafenib Mesylate是一种新颖，有效和选择性的Raf激酶抑制剂，能够抑制野生型B-Raf，B-RafV600E和c-Raf的激酶活性，IC50值分别为3.2、0.8和5.0 nM。

溶解度 *

In vitro DMSO 96 mg/mL (155.92 mM)
Water Insoluble
Ethanol 5 mg/mL (8.12 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.24 mL 81.21 mL 162.42 mL
0.5 mM 3.25 mL 16.24 mL 32.48 mL
1 mM 1.62 mL 8.12 mL 16.24 mL
5 mM 0.32 mL 1.62 mL 3.25 mL

*The above data is based on the productmolecular weight 615.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号 A15059
作用机制 Inhibitor (抑制剂)
M. Wt 615.67
Formula C24H24F3N5O5S3
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No. 1195768-06-9
Synonyms GSK-2118436 Mesylate, GSK2118436 Mesylate, GSK 2118436 Mesylate, GSK 2118436B
SMILES CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F.CS(=O)(=O)O

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