Dabrafenib Mesylate

Name: Dabrafenib Mesylate
SKU: A15059
Price: 245 CNY
Rating: 5 (288 reviews)

目录号: A15059

Raf 抑制剂

Dabrafenib Mesylate 是一种新型、高效、选择性的 Raf激酶抑制剂，能够抑制野生型B-Raf、B-RafV600E和c-Raf的激酶活性，其IC50值分别为3.2、0.8和5.0 nM。

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Grouped product items
规格	价格	库存
5mg	¥245.00	现货
10mg	¥350.00	现货
25mg	¥455.00	现货
50mg	¥560.00	现货
100mg	¥770.00	现货
500mg	¥1,610.00	现货
*10mM 1mL in DMSO**	¥350.00	现货
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Data Sheet

SDS

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生物活性

Discription

Dabrafenib Mesylate is a novel, potent, and selective Raf kinase inhibitor that is capableof inhibiting the kinase activity of wild-type B-Raf, B-RafV600Eand c-Raf with IC50 values of 3.2, 0.8, and 5.0 nM, respectively.

Targets

Target	Value

产品信息

目录号	A15059
分子式	C24H24F3N5O5S3
分子量	615.67
CAS号	1195768-06-9
SMILES	CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F.CS(=O)(=O)O
其他名称	GSK-2118436 Mesylate, GSK2118436 Mesylate, GSK 2118436 Mesylate, GSK 2118436B
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	96 mg/mL (155.92 mM)
	Water	Insoluble
	Ethanol	5 mg/mL (8.12 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.24 mL	81.21 mL	162.42 mL
0.5 mM	3.25 mL	16.24 mL	32.48 mL
1 mM	1.62 mL	8.12 mL	16.24 mL
5 mM	0.32 mL	1.62 mL	3.25 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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