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Dabrafenib Mesylate是一种新颖，有效和选择性的Raf激酶抑制剂，能够抑制野生型B-Raf，B-RafV600E和c-Raf的激酶活性，IC50值分别为3.2、0.8和5.0 nM。
| In vitro | DMSO | 96 mg/mL (155.92 mM) | |
| Water | Insoluble | ||
| Ethanol | 5 mg/mL (8.12 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.24 mL | 81.21 mL | 162.42 mL |
| 0.5 mM | 3.25 mL | 16.24 mL | 32.48 mL |
| 1 mM | 1.62 mL | 8.12 mL | 16.24 mL |
| 5 mM | 0.32 mL | 1.62 mL | 3.25 mL |
*The above data is based on the productmolecular weight 615.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15059 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 615.67 |
| Formula | C24H24F3N5O5S3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1195768-06-9 |
| Synonyms | GSK-2118436 Mesylate, GSK2118436 Mesylate, GSK 2118436 Mesylate, GSK 2118436B |
| SMILES | CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F.CS(=O)(=O)O |
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