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Dactolisib Tosylate (BEZ235 Tosylate) is a dual PI3K and mTOR kinase inhibitor with IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively. Dactolisib Tosylate (BEZ235 Tosylate) inhibits mTORC1 and mTORC2.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.58 mL | 77.91 mL | 155.83 mL |
| 0.5 mM | 3.12 mL | 15.58 mL | 31.17 mL |
| 1 mM | 1.56 mL | 7.79 mL | 15.58 mL |
| 5 mM | 0.31 mL | 1.56 mL | 3.12 mL |
*The above data is based on the productmolecular weight 641.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11327 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 641.74 |
| Formula | C37H31N5O4S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1028385-32-1 |
| Synonyms | BEZ235 (Tosylate); NVP-BEZ 235 (Tosylate) |
| SMILES | CN(C1=C2C3=CC(C4=CC5=CC=CC=C5N=C4)=CC=C3N=C1)C(N2C6=CC=C(C=C6)C(C)(C#N)C)=O.CC7=CC=C(S(=O)(O)=O)C=C7 |
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