Danicopan
目录号: A18609
Factor D 抑制剂
Danicopan（ACH-4471），一种选择性且口服活性的小分子因子D抑制剂，对人类因子D具有高结合亲和力，Kd值为0.54 nM。
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生物活性
| Discription | Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. |
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产品信息
| 目录号 | A18609 |
|---|---|
| 分子式 | C26H23BrFN7O3 |
| 分子量 | 580.41 |
| CAS号 | 1903768-17-1 |
| SMILES | O=C([C@H]1N(C(CN2N=C(C(C)=O)C3=C2C=CC(C4=CN=C(C)N=C4)=C3)=O)C[C@H](F)C1)NC5=NC(Br)=CC=C5 |
| 其他名称 | ACH-4471, ACH4471, ACH 4471 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 91 mg/mL (156.78 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.23 mL | 86.15 mL | 172.29 mL |
| 0.5 mM | 3.45 mL | 17.23 mL | 34.46 mL |
| 1 mM | 1.72 mL | 8.61 mL | 17.23 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.45 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1903768-17-1 | 1903768-17-1 供应商 | 1903768-17-1 花费 | 1903768-17-1 生产商 | 订购 1903768-17-1 | 1903768-17-1 代理商