Daphnetin

Name: Daphnetin
SKU: A10286

目录号: A10286

EGFR, PKA,PKC 抑制剂

Daphnetin Chemical Structure

CAS NO. 486-35-1

Daphnetin是一种香豆素类似物，可作为几种蛋白激酶的抑制剂。它在体外抑制EGFR激酶（IC50 = 7.67 ?M），PKA（IC50 = 9.33 ?M）和PKC（IC50 = 25 ?M）。蜂胶对EGFR激酶的抑制作用与ATP竞争，对肽底物没有竞争性。还可以用作有效的抗氧化剂和抗疟疾剂。

库存：现货

规格	价格	数量
10 mg	￥ 350.00
25 mg	￥ 700.00
50 mg	￥ 1,260.00
100 mg	￥ 2,240.00
10mM * 1mL in DMSO	￥ 476.00

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产品详情

生物活性

靶点信息

EGFR	PKA	PKC
7.67 μM	9.33 μM	25.01 μM

溶解度 *

In vitro	DMSO	33 mg/mL (185.24 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	56.15 mL	280.74 mL	561.48 mL
0.5 mM	11.23 mL	56.15 mL	112.3 mL
1 mM	5.61 mL	28.07 mL	56.15 mL
5 mM	1.12 mL	5.61 mL	11.23 mL

*The above data is based on the productmolecular weight 178.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10286
作用机制	Inhibitor (抑制剂)
M. Wt	178.1
Formula	C9H6O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	486-35-1
Synonyms	7,8-dihydroxycoumarin
SMILES	C1=CC(=C(C2=C1C=CC(=O)O2)O)O