DAPT (GSI-IX)

Name: DAPT (GSI-IX)
SKU: A10288
Price: 245 CNY
Rating: 5 (3 reviews)

目录号: A10288

Gamma secretase 抑制剂

3 篇发表文献

DAPT (GSI-IX) 是一种 γ-分泌酶 抑制剂，它能在人类原代神经细胞培养中降低 Aβ40 和 Aβ42 的水平，其 IC50 值分别为针对总 Aβ 的 115 nM 和针对 Aβ42 的 200 nM。

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Grouped product items
规格	价格	库存
5mg	¥245.00	现货
10mg	¥455.00	现货
25mg	¥1,120.00	现货
50mg	¥1,715.00	现货
100mg	¥2,765.00	现货
200mg	¥3,780.00	现货
500mg	¥6,090.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用DAPT (GSI-IX)发表的3篇文献

Kubra Telli, .et al. , Turkish Journal of Biochemistry, 2023, February 6

Paul Mark Medina, .et al. , Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682

Tatsuya Usui, .et al. , Int J Mol Sci, 2018, Apr; 19(4): 1098 PMID: 29642386

生物活性

Discription

DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10288
分子式	C23H26F2N2O4
分子量	432.5
CAS号	208255-80-5
SMILES	C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
其他名称	GSIIX
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	79 mg/mL (182.67 mM)
	Water	Insoluble
	Ethanol	46 mg/mL (106.36 mM)
In vivo	4% DMSO+corn oil	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.12 mL	115.61 mL	231.21 mL
0.5 mM	4.62 mL	23.12 mL	46.24 mL
1 mM	2.31 mL	11.56 mL	23.12 mL
5 mM	0.46 mL	2.31 mL	4.62 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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